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  • Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. 7667310

    The very low density lipoprotein (VLDL) receptor is a recently cloned member of the low density lipoprotein (LDL) receptor family that mediates the binding and uptake of VLDL when overexpressed in animal cells. Its sequence is 94% identical in humans and rabbits and 84% identical in humans and chickens, implying a conserved func...
    Tipo de documento:
    Referencia
    Referencia del producto:
    RI-13K
    Nombre del producto:
    Rat Insulin RIA

  • Binding of the radiolabeled glycine site antagonist [3H]MDL 105,519 to homomeric NMDA-NR1a receptors. 8894619

    We have characterized the binding of [3H]MDL 105,519 ((E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1 H-indole-2-carboxylic acid), a NMDA receptor glycine recognition site antagonist, to homomeric NMDA subunit 1a (NR 1a) receptors. Chinese hamster ovary cells (CHO-K1) were transfected with the rat NR 1a gene and cell lines stab...
    Tipo de documento:
    Referencia
    Referencia del producto:
    AP132A
    Nombre del producto:
    Goat Anti-Rabbit IgG Antibody, Alkaline Phosphatase conjugate

  • Erythropoietin produced by genetic-modified NIH/3T3 fibroblasts enhances the survival of degenerating neurons. 26357589

    Erythropoietin (EPO) has potent neuroprotective effects. The short-term delivery of high-dose EPO seemed to improve patients' neuromuscular functions; however, excessive EPO resulted in systematically high hematocrit and thrombotic risk. In our study, we established a cellular material for future in vivo studies of neurodeg...
    Tipo de documento:
    Referencia
    Referencia del producto:
    Múltiplo
    Nombre del producto:
    Múltiplo

  • Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells. 18957893

    Filamentous alpha-synuclein (alpha-syn) aggregates form Lewy bodies (LBs), the neuropathologic hallmarks of Parkinson disease and related alpha-synucleinopathies. To model Lewy body-associated neurodegeneration, we generated transfectant 3D5 of human neuronal-type in which expression of human wild-type alpha-syn is regulated by...
    Tipo de documento:
    Referencia
    Referencia del producto:
    AB5038P
    Nombre del producto:
    Anti-Synuclein α Antibody

  • Translational read-through of the RP2 Arg120stop mutation in patient iPSC-derived retinal pigment epithelium cells. 25292197

    Mutations in the RP2 gene lead to a severe form of X-linked retinitis pigmentosa. RP2 patients frequently present with nonsense mutations and no treatments are currently available to restore RP2 function. In this study, we reprogrammed fibroblasts from an RP2 patient carrying the nonsense mutation c.519Cgreater than T (p.R120X)...
    Tipo de documento:
    Referencia
    Referencia del producto:
    MAB5428
    Nombre del producto:
    Anti-Retinal Pigment Epithelium 65 Antibody

  • Identification, selection, and enrichment of cardiomyocyte precursors. 23853770

    The large-scale production of cardiomyocytes is a key step in the development of cell therapy and tissue engineering to treat cardiovascular diseases, particularly those caused by ischemia. The main objective of this study was to establish a procedure for the efficient production of cardiomyocytes by reprogramming mesenchymal st...
    Tipo de documento:
    Referencia
    Referencia del producto:
    Múltiplo
    Nombre del producto:
    Múltiplo

  • METCAM/MUC18 augments migration, invasion, and tumorigenicity of human breast cancer SK-BR-3 cells. 22057013

    Previous research has identified METCAM/MUC18, an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family, as a promoter or a suppressor in the development of human breast cancer by MCF7, MDA-MB-231, and MDA-MB-468. To resolve these conflicting results we have investigated the role of this CAM in the prog...
    Tipo de documento:
    Referencia
    Referencia del producto:
    AP162A
    Nombre del producto:
    Rabbit Anti-Chicken IgG Antibody, Alkaline Phosphatase conjugate

  • Up-regulation of METCAM/MUC18 promotes motility, invasion, and tumorigenesis of human breast cancer cells. 21450088

    Conflicting research has identified METCAM/MUC18, an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family, as both a tumor promoter and a tumor suppressor in the development of breast cancer. To resolve this, we have re-investigated the role of this CAM in the progression of human breast cancer cells.T...
    Tipo de documento:
    Referencia
    Referencia del producto:
    Múltiplo
    Nombre del producto:
    Múltiplo

  • Bub1-mediated adaptation of the spindle checkpoint. 21298086

    During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules. The spindle checkpoint is deactivated as chromosomes start moving toward the spi...
    Tipo de documento:
    Referencia
    Referencia del producto:
    07-144
    Nombre del producto:
    Anti-Numb p72/p71 Antibody