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  • Dimethyl Sulfoxide (DMSO) -2802494

    Tipo de documento:
    Certificado de análisis
    Número de lote:
    2802494
    Referencia del producto:
    20-139
    Nombre del producto:
    Dimethyl Sulfoxide (DMSO)

  • Dimethyl Sulfoxide (DMSO) -2776729

    Tipo de documento:
    Certificado de análisis
    Número de lote:
    2776729
    Referencia del producto:
    20-139
    Nombre del producto:
    Dimethyl Sulfoxide (DMSO)

  • Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2. 17360627

    During cell division, cessation of transcription is coupled with mitotic chromosome condensation. A fundamental biological question is how gene expression patterns are retained during mitosis to ensure the phenotype of progeny cells. We suggest that cell fate-determining transcription factors provide an epigenetic mechanism for the retention of gene expression patterns during cell division. Runx proteins are lineage-specific transcription factors that are essential for hematopoietic, neuronal, gastrointestinal, and osteogenic cell fates. Here we show that Runx2 protein is stable during cell division and remains associated with chromosomes during mitosis through sequence-specific DNA binding. Using siRNA-mediated silencing, mitotic cell synchronization, and expression profiling, we identify Runx2-regulated genes that are modulated postmitotically. Novel target genes involved in cell growth and differentiation were validated by chromatin immunoprecipitation. Importantly, we find that during mitosis, when transcription is shut down, Runx2 selectively occupies target gene promoters, and Runx2 deficiency alters mitotic histone modifications. We conclude that Runx proteins have an active role in retaining phenotype during cell division to support lineage-specific control of gene expression in progeny cells.
    Tipo de documento:
    Referencia
    Referencia del producto:
    06-946