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681525 Wiskostatin - CAS 253449-04-6 - Calbiochem

A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly.

Wiskostatin - CAS 253449-04-6 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: N-WASP (neural Wiskott Aldrich syndrome protein)
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681525
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
253449-04-6C₁₇H₁₈Br₂N₂O

Precios y disponibilidad

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681525-1MG
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      Description
      OverviewA cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.
      Catalogue Number681525
      Brand Family Calbiochem®
      References
      ReferencesPeterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
      Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.
      Product Information
      CAS number253449-04-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₇H₁₈Br₂N₂O
      Chemical formulaC₁₇H₁₈Br₂N₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetN-WASP (neural Wiskott Aldrich syndrome protein)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      681525-1MG 04055977260090

      Documentation

      Wiskostatin - CAS 253449-04-6 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Wiskostatin - CAS 253449-04-6 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      681525

      Referencias bibliográficas

      Visión general referencias
      Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
      Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-April-2008 RFH
      DescriptionA cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of neural Wiskott Aldrich Syndrome protein (N-WASP). Reported to bind to N-WASP, stabilize the auto-inhibited conformation, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number253449-04-6
      Chemical formulaC₁₇H₁₈Br₂N₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPeterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
      Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.