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553210 Rapamycin - CAS 53123-88-9 - Calbiochem

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Rapamycin - CAS 53123-88-9 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: mTOR Inhibitor I

Primary Target: Mammalian target of rapamycin (mTOR)
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553210
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
53123-88-9C₅₁H₇₉NO₁₃

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
553210-100UG
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      553210-1MG
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          553210-5MG
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              Description
              OverviewAnti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
              Catalogue Number553210
              Brand Family Calbiochem®
              SynonymsmTOR Inhibitor I
              References
              ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
              Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
              Braun, W., et al. 1995. FASEB J. 9, 63.
              Nielsen, F.C., et al. 1995. Nature 377, 358.
              Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
              Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
              Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
              Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
              Kuo, J., et al. 1992. Nature 358, 70.
              Price, D.J., et al. 1992. Science 257, 973.
              Heitman, J., et al. 1991. Science 253, 905.
              Kay, J.E., et al. 1991. Immunology 72, 544.
              Schreiber, S.L. 1991. Science 251, 283.
              Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
              Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
              Product Information
              CAS number53123-88-9
              ATP CompetitiveN
              FormClear film
              Hill FormulaC₅₁H₇₉NO₁₃
              Chemical formulaC₅₁H₇₉NO₁₃
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              Biological Information
              Primary TargetMammalian target of rapamycin (mTOR)
              Primary Target IC<sub>50</sub>50 pM against p70 S6 kinase
              Purity≥99% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSVE6250000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Número de referencia GTIN
              553210-100UG 04055977193510
              553210-1MG 04055977193480
              553210-5MG 04055977193534

              Documentation

              Rapamycin - CAS 53123-88-9 - Calbiochem Ficha datos de seguridad (MSDS)

              Título

              Ficha técnica de seguridad del material (MSDS) 

              Rapamycin - CAS 53123-88-9 - Calbiochem Certificados de análisis

              CargoNúmero de lote
              553210

              Referencias bibliográficas

              Visión general referencias
              Chen, T., et al. 2011. Aging Cell. 10, 908.
              Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
              Braun, W., et al. 1995. FASEB J. 9, 63.
              Nielsen, F.C., et al. 1995. Nature 377, 358.
              Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
              Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
              Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
              Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
              Kuo, J., et al. 1992. Nature 358, 70.
              Price, D.J., et al. 1992. Science 257, 973.
              Heitman, J., et al. 1991. Science 253, 905.
              Kay, J.E., et al. 1991. Immunology 72, 544.
              Schreiber, S.L. 1991. Science 251, 283.
              Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
              Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

              Folleto

              Cargo
              Bulk Product Guide
              Caspases and other Apoptosis Related Tools Brochure

              Ficha técnica

              Cargo
              Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

              Póster

              Cargo
              Human Kinome & InhibitorSelect™ Libraries

              Citas

              Título
            • Chen, T., et al. 2011. Aging Cell. 10, 908.
            • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
            • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
            • Liao, X., et al. 2003. Endocrinology 144, 1656.
              		•
              Ficha técnica

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision11-September-2014 JSW
              SynonymsmTOR Inhibitor I
              DescriptionSelectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
              FormClear film
              CAS number53123-88-9
              RTECSVE6250000
              Chemical formulaC₅₁H₇₉NO₁₃
              Structure formulaStructure formula
              Purity≥99% by HPLC
              SolubilityDMSO (200 mg/ml) or Ethanol (50 mg/ml)
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              Merck USA index14, 8114
              ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
              Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
              Braun, W., et al. 1995. FASEB J. 9, 63.
              Nielsen, F.C., et al. 1995. Nature 377, 358.
              Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
              Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
              Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
              Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
              Kuo, J., et al. 1992. Nature 358, 70.
              Price, D.J., et al. 1992. Science 257, 973.
              Heitman, J., et al. 1991. Science 253, 905.
              Kay, J.E., et al. 1991. Immunology 72, 544.
              Schreiber, S.L. 1991. Science 251, 283.
              Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
              Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
              Citation
            • Chen, T., et al. 2011. Aging Cell. 10, 908.
            • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
            • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
            • Liao, X., et al. 2003. Endocrinology 144, 1656.
              		•