Millipore Sigma Vibrant Logo

616387 Nα-Tosyl-Phe Chloromethyl Ketone

Irreversible inhibitor of chymotrypsin.

Nα-Tosyl-Phe Chloromethyl Ketone: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: TPCK

Primary Target: chymotrypsin activity in preparations
View Products on Sigmaaldrich.com
616387
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
402-71-1C₁₇H₁₈ClNO₃S

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
616387-250MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 250 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      Description
      Overview

      This product has been discontinued.





      Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides (EC50 = 20 µM).
      Catalogue Number616387
      Brand Family Calbiochem®
      SynonymsTPCK
      References
      ReferencesFearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
      Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279.
      Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229.
      Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.
      Product Information
      CAS number402-71-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₇H₁₈ClNO₃S
      Chemical formulaC₁₇H₁₈ClNO₃S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetchymotrypsin activity in preparations
      Primary Target IC<sub>50</sub>EC50 = 20 µM in blocking the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides.
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXT5613500
      Safety Information
      R PhraseR: 41

      Risk of serious damage to eyes.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      616387-250MG 04055977186314

      Documentation

      Nα-Tosyl-Phe Chloromethyl Ketone Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Nα-Tosyl-Phe Chloromethyl Ketone Certificados de análisis

      CargoNúmero de lote
      616387

      Referencias bibliográficas

      Visión general referencias
      Fearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
      Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279.
      Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229.
      Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.

      Citas

      Título
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
      		•
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-September-2008 RFH
      SynonymsTPCK
      DescriptionIrreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharide (EC50 = 20 µM). Suggested working concentration is 10-100 µM.
      FormWhite solid
      CAS number402-71-1
      RTECSXT5613500
      Chemical formulaC₁₇H₁₈ClNO₃S
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityEthanol (5 mg/ml) or Methanol (5 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
      Toxicity Irritant
      ReferencesFearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
      Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279.
      Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229.
      Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.
      Citation
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
      		•