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420320 KT5720 - CAS 108068-98-0 - Calbiochem

KT5720, CAS 108068-98-0, is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Has no significant effect on PKC, PKG & MLCK.

KT5720 - CAS 108068-98-0 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: PKA Inhibitor VII

Primary Target: PKA
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420320
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
108068-98-0C₃₂H₃₁N₃O₅

Precios y disponibilidad

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420320-100UG
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      		 Frasco de vidrio 100 μg
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      420320-50UG
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          Contact Customer Service

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          Description
          OverviewA potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a. Does not significantly affect the activities of PKC, PKG, and MLCK. Inhibits axon branching in cultured neurons. A 2 mM (50 µg/47 µl) solution of KT 5720 (Cat. No. 420323) in DMSO is also available.
          Catalogue Number420320
          Brand Family Calbiochem®
          SynonymsPKA Inhibitor VII
          References
          ReferencesSimpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
          Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
          Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
          Product Information
          CAS number108068-98-0
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₃₂H₃₁N₃O₅
          Chemical formulaC₃₂H₃₁N₃O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationKT5720, CAS 108068-98-0, is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Has no significant effect on PKC, PKG & MLCK.
          Biological Information
          Primary TargetPKA
          Primary Target K<sub>i</sub>56 nM for protein kinase A
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          420320-100UG 04055977211023
          420320-50UG 04055977211030

          Documentation

          KT5720 - CAS 108068-98-0 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          KT5720 - CAS 108068-98-0 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          420320

          Referencias bibliográficas

          Visión general referencias
          Simpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
          Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
          Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

          Citas

          Título
        • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
          		•
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-January-2010 RFH
          SynonymsPKA Inhibitor VII
          DescriptionPrepared by a chemical modification of K-252a. A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Does not significantly affect the activity of PKC, PKG, or MLCK. Inhibits axon branching in cultured neurons.
          FormWhite solid
          CAS number108068-98-0
          Chemical formulaC₃₂H₃₁N₃O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (1 mg/ml). Further dilute with aqueous buffers just prior to use.
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSimpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
          Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
          Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
          Citation
        • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
          		•