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407950 Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem

Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
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407950
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
56092-81-0C₄₁H₇₂O₉

Precios y disponibilidad

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407950-1MG
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      407950-5MG
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          Description
          OverviewHighly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.
          Absorption max. (280 nm, MeOH): 18,600 M-1cm-1.
          Catalogue Number407950
          Brand Family Calbiochem®
          References
          ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
          Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
          Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
          Lee, H.C. 1993. J. Biol. Chem. 268, 293.
          Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
          Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
          Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
          Product Information
          CAS number56092-81-0
          ATP CompetitiveN
          FormWaxy solid
          Hill FormulaC₄₁H₇₂O₉
          Chemical formulaC₄₁H₇₂O₉
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationIonomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.
          Biological Information
          Primary TargetMobile ion carrier for Ca2+
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSNO0600000
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          407950-1MG 04055977211559
          407950-5MG 04055977211573

          Documentation

          Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          407950

          Referencias bibliográficas

          Visión general referencias
          Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
          Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
          Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
          Lee, H.C. 1993. J. Biol. Chem. 268, 293.
          Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
          Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
          Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.

          Folleto

          Cargo
          Caspases and other Apoptosis Related Tools Brochure

          Citas

          Título
        • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
          		•
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-April-2010 JSW
          DescriptionHighly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
          FormWaxy solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number56092-81-0
          RTECSNO0600000
          Chemical formulaC₄₁H₇₂O₉
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (10 mg/ml) and Methanol (10 mg/ml)
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
          Toxicity Harmful
          ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
          Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
          Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
          Lee, H.C. 1993. J. Biol. Chem. 268, 293.
          Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
          Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
          Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
          Citation
        • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
          		•

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          Categorías

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores