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CC077 Human Collagen Type V

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CC077
100 µg  
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      Descripción

      Tabla espec. clave

      Key Applications
      CULT
      Description
      Catalogue NumberCC077
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionHuman Collagen Type V
      OverviewPROPERTIES:

      Molecular composition: [alpha1(V)]2 alpha2(V), native triple helix.

      Purity and retention of native helical structure was monitored by SDS-PAGE, ORD measurement, and by reaction with anti-collagen type-specific monoclonal antibodies.
      Product Information
      PresentationLiquid, in 0.1M acetic acid, pH 3.0. No preservatives added.
      Quality LevelMQ100
      Applications
      Key Applications
      • Cell Culture
      Biological Information
      Concentration1 mg/ml
      Purity95% by SDS-PAGE

      Contaminants: <2% collagen type I, <1% collagen type III, <2% collagen type IV and <0.5% non-collagen proteins.

      PURIFICATION:

      Purified by serial salt precipitations of a pepsin extraction of human fetal membranes and chromatography on DEAE-cellulose.
      SourceHuman placenta, negative for HBsAG and HIV antibodies.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II.
      Gene Symbol
      • COL5A1
      • OTTHUMP00000064637
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20908 # Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
      SIZE: 1838 amino acids; 183560 Da
      SUBUNIT: Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
      PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & Sulfated on 40% of tyrosines.
      DISEASE: SwissProt: P20908 # Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type I (EDS-I) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis. EDS-I is a connective-tissue disorder characterized by loose-jointedness and fragile, velvety, stretchable, bruisable skin that heals with peculiar 'cigarette-paper' scars. Inheritance is autosomal dominant. & Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type II (EDS-II) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis. Inheritance is autosomal dominant.
      SIMILARITY: SwissProt: P20908 ## Belongs to the fibrillar collagen family. & Contains 1 laminin G-like domain. & Contains 1 TSP N-terminal (TSPN) domain.
      Stem Cell Type
      • Human Embryonic Stem Cells
      • Mesenchymal Stem Cells
      • Neural Stem Cells
      • Hematopoietic Stem Cells
      • Epithelial Cells
      • Pancreatic Stem Cells
      • Induced Pluripotent Stem Cells
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months. Do not thaw and refreeze.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Número de referencia GTIN
      CC077 04053252327070