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345834 Genistein, Soybean - CAS 446-72-0 - Calbiochem

A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 4ʹ,5,7-Trihydroxyisoflavone

Primary Target: EGFR kinase
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345834
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Tabla espec. clave

CAS #Empirical Formula
446-72-0C₁₅H₁₀O₅

Precios y disponibilidad

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345834-20MG
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      Description
      OverviewA cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC50 > 350 µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro.
      Catalogue Number345834
      Brand Family Calbiochem®
      Synonyms4ʹ,5,7-Trihydroxyisoflavone
      References
      ReferencesConstantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
      Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
      Wei, H., et al. 1995. Carcinogenesis 17, 73.
      Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
      Migita, K., et al. 1994. J. Immunol. 153, 3457.
      Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
      Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
      Hill, T.D., et al. 1990. Science 248, 1660.
      Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
      Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
      Product Information
      CAS number446-72-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₁₀O₅
      Chemical formulaC₁₅H₁₀O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR kinase
      Primary Target IC<sub>50</sub>2.6 µM against autophosphorylation of epidermal growth factor receptor kinase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNR2392000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      345834-20MG 04055977214376

      Documentation

      Genistein, Soybean - CAS 446-72-0 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Genistein, Soybean - CAS 446-72-0 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      345834

      Referencias bibliográficas

      Visión general referencias
      Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
      Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
      Wei, H., et al. 1995. Carcinogenesis 17, 73.
      Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
      Migita, K., et al. 1994. J. Immunol. 153, 3457.
      Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
      Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
      Hill, T.D., et al. 1990. Science 248, 1660.
      Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
      Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.

      Folleto

      Cargo
      Caspases and other Apoptosis Related Tools Brochure

      Citas

      Título
    • Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.
      		•
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-April-2010 JSW
      Synonyms4ʹ,5,7-Trihydroxyisoflavone
      DescriptionA cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits exogenous substrate phosphorylation by EGFR kinase and pp60v-src with similar potencies (IC50 = 20-25 µM). Has only a trivial effect on PKC and PKA (IC50 >350 µM). Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro. Blocks oxidative DNA damage in vitro.
      FormWhite solid
      CAS number446-72-0
      RTECSNR2392000
      Chemical formulaC₁₅H₁₀O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 4391
      ReferencesConstantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
      Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
      Wei, H., et al. 1995. Carcinogenesis 17, 73.
      Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
      Migita, K., et al. 1994. J. Immunol. 153, 3457.
      Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
      Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
      Hill, T.D., et al. 1990. Science 248, 1660.
      Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
      Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
      Citation
    • Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.
      		•