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361550 GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

Descripción

Tabla espec. clave

CAS #Empirical Formula
667463-62-9C₁₆H₁₀BrN₃O₂

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361550-1MG
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      Description
      OverviewA cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Its specificity has been tested against various Cdk's (IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50 ≥ 10 µM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361552) in DMSO is also available.
      Catalogue Number361550
      Brand Family Calbiochem®
      SynonymsBIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
      References
      ReferencesTseng, A-S., et al. 2006. Chem. Biol. 13, 957.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Sato, N., et al. 2004. Nat. Med. 10, 55.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Product Information
      CAS number667463-62-9
      ATP CompetitiveY
      FormPurple solid
      Hill FormulaC₁₆H₁₀BrN₃O₂
      Chemical formulaC₁₆H₁₀BrN₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetGSK-3α/β
      Primary Target IC<sub>50</sub>5 nM against GSK-3α/β
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36/37

      Do not breathe dust.
      Wear suitable protective clothing and gloves.
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      361550-1MG 04055977214062