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371818 G-Protein βγ Binding Peptide, mSIRK - Calbiochem

A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: mSIRK, myr-SIRKALNILGYPDYD-OH

Primary Target: N-myristoylated G-protein βγ selective binding
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371818
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₉₃H₁₅₀N₂₀O₂₅

Precios y disponibilidad

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371818-1MG
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      Description
      OverviewA cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC50 ~ 2.5 - 5 µM) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca2+ release from internal stores. Negative control is also available (Cat. No. 371820).
      Catalogue Number371818
      Brand Family Calbiochem®
      SynonymsmSIRK, myr-SIRKALNILGYPDYD-OH
      References
      ReferencesGoubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
      Scott, J.K., et al. 2001. EMBO J. 20, 767.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₉₃H₁₅₀N₂₀O₂₅
      Chemical formulaC₉₃H₁₅₀N₂₀O₂₅
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetN-myristoylated G-protein βγ selective binding
      Primary Target IC<sub>50</sub>EC50 ~ 2.5 - 5 µM in activation of ERK1/2 in rat arterial smooth muscle and Rat2 cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceMyr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      371818-1MG 04055977213423

      Documentation

      G-Protein βγ Binding Peptide, mSIRK - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      G-Protein βγ Binding Peptide, mSIRK - Calbiochem Certificados de análisis

      CargoNúmero de lote
      371818

      Referencias bibliográficas

      Visión general referencias
      Goubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
      Scott, J.K., et al. 2001. EMBO J. 20, 767.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-July-2008 RFH
      SynonymsmSIRK, myr-SIRKALNILGYPDYD-OH
      DescriptionA cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange. Reported to cause a rapid activation of ERK1/2 (EC50 ~2.5-5 µM) in RASM (rat arterial smooth muscle) and Rat2 cells. Promotes the phosphorylation of JNK and p38 MAP kinase. Also increases phospholipase C activity and causes Ca2+ release from internal stores.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₉₃H₁₅₀N₂₀O₂₅
      Peptide SequenceMyr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C
      Toxicity Standard Handling
      ReferencesGoubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
      Scott, J.K., et al. 2001. EMBO J. 20, 767.