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371818 G-Protein βγ Binding Peptide, mSIRK - Calbiochem

A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide

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Sinónimos: mSIRK, myr-SIRKALNILGYPDYD-OH

Primary Target: N-myristoylated G-protein βγ selective binding
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371818
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Descripción

Tabla espec. clave

Empirical Formula
C₉₃H₁₅₀N₂₀O₂₅

Precios y disponibilidad

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371818-1MG
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      Description
      OverviewA cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC50 ~ 2.5 - 5 µM) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca2+ release from internal stores. Negative control is also available (Cat. No. 371820).
      Catalogue Number371818
      Brand Family Calbiochem®
      SynonymsmSIRK, myr-SIRKALNILGYPDYD-OH
      References
      ReferencesGoubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
      Scott, J.K., et al. 2001. EMBO J. 20, 767.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₉₃H₁₅₀N₂₀O₂₅
      Chemical formulaC₉₃H₁₅₀N₂₀O₂₅
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary TargetN-myristoylated G-protein βγ selective binding
      Primary Target IC<sub>50</sub>EC50 ~ 2.5 - 5 µM in activation of ERK1/2 in rat arterial smooth muscle and Rat2 cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceMyr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      371818-1MG 04055977213423