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196805 Bax Channel Blocker - CAS 335165-69-0 - Calbiochem

Descripción

Tabla espec. clave

CAS #Empirical Formula
335165-69-0C₁₉H₂₁Br₂N₃O

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196805-5MG
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      Description
      OverviewA cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel-forming activity (IC50 = 520 nM in a liposome channel assay).
      Catalogue Number196805
      Brand Family Calbiochem®
      Synonyms(±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1
      References
      ReferencesPeixoto, P., et al. 2009. Biochem J. 423, 381.
      Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.
      Product Information
      CAS number335165-69-0
      ATP CompetitiveN
      FormOff-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₉H₂₁Br₂N₃O
      Chemical formulaC₁₉H₂₁Br₂N₃O
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary TargetBax-channel forming activity
      Primary Target IC<sub>50</sub>520 nM blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity in a liposome channel assay
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      196805-5MG 04055977206524