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196418 BAPTA, Tetrasodium Salt

Descripción

Tabla espec. clave

CAS #Empirical Formula
126824-24-6C₂₂H₂₀N₂O₁₀ · 4Na

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196418-1GM
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      Description
      OverviewCa2+ chelator exhibiting a 105-fold greater affinity for Ca2+ (Kd = 110 nM) than for Mg2+. After BAPTA complexes with Ca2+, the UV spectrum shifts from 254 to 279 nm at pH >6.0. Useful for spectrophotometric monitoring of extracellular Ca2+ levels, especially transient phenomena, because of its insensitivity to pH. Useful for the measurement and control of Ca2+ levels in eggs, chromaffin cells, muscle cells, retinal cells, and pancreatic cells. In conjunction with certain formazan dyes, BAPTA can be used in a colorimetric assay for Mg2+. Has neuroprotective effects in vitro against excitotoxic damage and spontaneous recurrent seizures, such as epilepsy.
      Catalogue Number196418
      Brand Family Calbiochem®
      Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid, 4Na
      References
      ReferencesDeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
      Li, L., et al. 1995. J. Cell Physiol. 163, 105.
      Tymianski, M., et al. 1994. J. Neurophysiol. 72, 1973.
      Product Information
      CAS number126824-24-6
      FormWhite to off-white solid
      Hill FormulaC₂₂H₂₀N₂O₁₀ · 4Na
      Chemical formulaC₂₂H₂₀N₂O₁₀ · 4Na
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). To increase stability in solution, store at a high pH (>10). Stock solutions are stable for up to 1 month at -20°C.
      Global Trade Item Number
      Número de referencia GTIN
      196418-1GM 04055977206470