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123040 AICA-Riboside - CAS 2627-69-2 - Calbiochem

AICA-Riboside, CAS 2627-69-2, is a cell-permeable nucleoside compound whose phosphorylated metabolite activates AMPK and acts as a regulator of de novo purine synthesis.

AICA-Riboside - CAS 2627-69-2 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Acadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-riboside, Z-Riboside, AMPK Signaling Activator II

Primary Target: Adenosine monophosphate-activated protein kinase (AMPK)
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123040
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Descripción

Tabla espec. clave

CAS #Empirical Formula
2627-69-2C₉H₁₄N₄O₅

Precios y disponibilidad

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123040-50MG
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      Description
      OverviewA cell-permeable nucleoside compound whose phosphorylated metabolite activates adenosine monophosphate-activated protein kinase (AMPK) and acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in perfused and isolated muscle. Offers protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and Aβ peptide.
      Catalogue Number123040
      Brand Family Calbiochem®
      SynonymsAcadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-riboside, Z-Riboside, AMPK Signaling Activator II
      References
      ReferencesMeli, M., et al. 2006. J. Med. Chem. in press.
      Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45.
      Muoio, D.M., et al. 1999. Biochem. J. 338, 783.
      Hayashi, T., et al. 1998. Diabetes 47, 1369.
      Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.
      Product Information
      CAS number2627-69-2
      ATP CompetitiveN
      FormWhite to brown solid
      Hill FormulaC₉H₁₄N₄O₅
      Chemical formulaC₉H₁₄N₄O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetAdenosine monophosphate-activated protein kinase (AMPK)
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      123040-50MG 04055977206272