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101500 AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem

AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl

Primary Target: chymotrypsin
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101500
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
30827-99-7C₈H₁₀FNO₂S · HCl

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
101500-100MG
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      101500-500MG
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          101500-50MG
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              Description
              OverviewSpecific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications. Also available as a 50 mM solution in H2O (Cat. No. 508436).
              Catalogue Number101500
              Brand Family Calbiochem®
              Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl
              Application Data
              References
              ReferencesCitron, M., et al. 1996. Neuron 17, 171.
              Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
              Mintz, G.R. 1993. BioPharm. 6, 34.
              Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
              Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
              Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
              Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
              Product Information
              CAS number30827-99-7
              ATP CompetitiveN
              FormWhite to off-white solid
              Hill FormulaC₈H₁₀FNO₂S · HCl
              Chemical formulaC₈H₁₀FNO₂S · HCl
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary Targetchymotrypsin
              Purity>97% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Número de referencia GTIN
              101500-100MG 04055977226317
              101500-500MG 04055977226348
              101500-50MG 04055977226331

              Documentation

              AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem Ficha datos de seguridad (MSDS)

              Título

              Ficha técnica de seguridad del material (MSDS) 

              AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem Certificados de análisis

              CargoNúmero de lote
              101500

              Referencias bibliográficas

              Visión general referencias
              Citron, M., et al. 1996. Neuron 17, 171.
              Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
              Mintz, G.R. 1993. BioPharm. 6, 34.
              Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
              Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
              Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
              Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.

              Folleto

              Cargo
              Bulk Product Guide

              Citas

              Título
            • Catherine Mee-Hie Cho, Ashok Mulchandani and Wilfred Chen. (2006) Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides. Protein Engineering Design and Selection 19, 99-105.
            • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
            • Sharon Yagur-Kroll and Orna Amster-Choder. (2005) Dynamic membrane topology of the E. coli -glucoside transporter β-glucosidase transporter BglF. Journal of Biological Chemistry 280, 19306-19318.
            • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
              		•
              Ficha técnica

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision27-September-2013 JSW
              Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl
              Application Data
              DescriptionSpecific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K.
              FormWhite to off-white solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number30827-99-7
              Chemical formulaC₈H₁₀FNO₂S · HCl
              Structure formulaStructure formula
              Purity>97% by HPLC
              SolubilityH₂O (25 mg/ml)
              Storage Protect from moisture
              -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
              Toxicity Standard Handling
              ReferencesCitron, M., et al. 1996. Neuron 17, 171.
              Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
              Mintz, G.R. 1993. BioPharm. 6, 34.
              Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
              Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
              Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
              Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
              Citation
            • Catherine Mee-Hie Cho, Ashok Mulchandani and Wilfred Chen. (2006) Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides. Protein Engineering Design and Selection 19, 99-105.
            • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
            • Sharon Yagur-Kroll and Orna Amster-Choder. (2005) Dynamic membrane topology of the E. coli -glucoside transporter β-glucosidase transporter BglF. Journal of Biological Chemistry 280, 19306-19318.
            • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
              		•

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              Categorías

              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors