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100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem

A mobile ion-carrier that forms stable complexes with divalent cations.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Calcimycin

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100105
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
52665-69-7C₂₉H₃₇N₃O₆

Precios y disponibilidad

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100105-1MG
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      100105-5MG
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          Description
          OverviewA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
          Catalogue Number100105
          Brand Family Calbiochem®
          SynonymsCalcimycin
          References
          ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
          Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
          Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
          Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
          Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
          Product Information
          CAS number52665-69-7
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₉H₃₇N₃O₆
          Chemical formulaC₂₉H₃₇N₃O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetMitochondrial ATPase
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDM4676000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          100105-1MG 04055977226225
          100105-5MG 04055977226249

          Documentation

          A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          100105

          Referencias bibliográficas

          Visión general referencias
          Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
          Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
          Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
          Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
          Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

          Folleto

          Cargo
          Caspases and other Apoptosis Related Tools Brochure
          Tools and Tips for Analyzing Apoptosis
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          SynonymsCalcimycin
          DescriptionA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
          FormWhite solid
          CAS number52665-69-7
          RTECSDM4676000
          Chemical formulaC₂₉H₃₇N₃O₆
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO or Methanol. For use in aqueous systems, preparation of a 100 mM stock in DMSO is recommended. Microliter amounts of this solution can then be added to H₂O with rapid mixing (e.g. 10 µl into 5 ml of H₂O). In aqueous systems, the ionophore aggregates over time.
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 1639
          ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
          Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
          Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
          Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
          Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

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          Categorías

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores