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324355 n-Dodecyl-β-D-maltoside, ULTROL® Grade - CAS 69227-93-6 - Calbiochem

CAS 69227-93-6 is a non-ionic detergent similar to n-octyl-β-D-glucopyranoside; however, increased alkyl chain length has been shown to increase thermal stability of lipid-free rhodopsin in solution.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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324355
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Overview

Replacement Information

Key Spec Table

CAS #
69227-93-6

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      324355-5GM
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          Description
          OverviewNon-ionic detergent similar to n-octyl-β-D-glucopyranoside; however, increased alkyl chain length has been shown to increase thermal stability of lipid-free rhodopsin in solution. Useful in membrane-protein solubilization studies. Aggregation number: 98.
          Absorbance (10%, H2O, 260 nm): <1.0.
          Catalogue Number324355
          Brand Family Calbiochem®
          References
          ReferencesWitzmann, F., et al. 1991. Electrophoresis 12, 687.
          Bass, W.T., and Bricker, T.M. 1988. Anal. Biochem. 171, 330.
          Rosevear, P., et al. 1980. Biochemistry 19, 4108.
          Grip, W.J., and Bovee-Geurts, P.H.M. 1979. Chem. Phys. Lipids 23, 321.
          Stubbs, G.W., et al. 1976. Biochim. Biophys. Acta 425, 46.
          Product Information
          CAS number69227-93-6
          Aggregation Number98
          CMC100-600 µM
          FormWhite solid
          Hygroscopic Hygroscopic
          Micellar weight50000
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Contaminantsdodecanol 1H NMR: ≤1%
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C).
          Stock solutions are stable for up to 3 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          324355-1GM 07790788054175
          324355-5GM 04055977216448

          Documentation

          n-Dodecyl-β-D-maltoside, ULTROL® Grade - CAS 69227-93-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          n-Dodecyl-β-D-maltoside, ULTROL® Grade - CAS 69227-93-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          324355

          References

          Reference overview
          Witzmann, F., et al. 1991. Electrophoresis 12, 687.
          Bass, W.T., and Bricker, T.M. 1988. Anal. Biochem. 171, 330.
          Rosevear, P., et al. 1980. Biochemistry 19, 4108.
          Grip, W.J., and Bovee-Geurts, P.H.M. 1979. Chem. Phys. Lipids 23, 321.
          Stubbs, G.W., et al. 1976. Biochim. Biophys. Acta 425, 46.

          Brochure

          Title
          Biological Detergents Brochure
          CALBIOSORBﾙ Technical Bulletin

          Citations

          Title
        • Serban P. Georgescu, et al. (2005) Modulator recognition factor 1 (MRF1), an ARID-family member, is a novel co-repressor for estrogen receptor α. Molecular Endocrinology 19, 2491-2501.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-December-2010 JSW
          DescriptionA water-soluble nonionic detergent. Studies on rhodopsin have shown that alkyl glycosides with longer alkyl chains are better at preserving the protein's properties. In addition, dodecyl maltoside's longer hydrophilic group confers higher solubility in water. This is in contrast to undecyl and dodecyl glucosides, which have low solubility in water. Due to its low CMC, dodecyl maltoside is not easily removed by dialysis. The half time for dialysis is 20 h. This detergent is milder than nonyl glucoside. Of several glycosides tested, dodecyl maltoside was found to be the most useful for the preparation of active cytochrome oxidase from Neurospora. In octyl glucoside, cytochrome oxidase dissociated into its subunits and became inactive. Similarly, beef heart oxidase when equilibrated in octyl glucoside formed a mixture of polymer, dimer, and lower molecular weight forms and underwent denaturation. In contrast, the enzyme, when equilibrated in dodecyl maltoside, was found to exist as a uniform species of 30 kDa, which is consistent with an active dimeric form. Dodecyl maltoside has a critical micelle concentration (CMC) of 100-600 µM and a micellar weight of 70,000. Aggregation number: 98.
          FormWhite solid
          CAS number69227-93-6
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Contaminantsdodecanol 1H NMR: ≤1%
          SolubilityH₂O (100 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C).
          Stock solutions are stable for up to 3 months at 4°C.
          Toxicity Standard Handling
          ReferencesWitzmann, F., et al. 1991. Electrophoresis 12, 687.
          Bass, W.T., and Bricker, T.M. 1988. Anal. Biochem. 171, 330.
          Rosevear, P., et al. 1980. Biochemistry 19, 4108.
          Grip, W.J., and Bovee-Geurts, P.H.M. 1979. Chem. Phys. Lipids 23, 321.
          Stubbs, G.W., et al. 1976. Biochim. Biophys. Acta 425, 46.
          Citation
        • Serban P. Georgescu, et al. (2005) Modulator recognition factor 1 (MRF1), an ARID-family member, is a novel co-repressor for estrogen receptor α. Molecular Endocrinology 19, 2491-2501.
          		•