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108219 Tris(hydroxymethyl)aminomethane hydrochloride

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Trometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer

CAS #: 1185-53-1 EC Number: 214-684-5 Molar Mass: 157.60 g/mol Chemical Formula: C₄H₁₁NO₃*ClH Hill Formula: C₄H₁₁NO₃˙ ClH
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108219
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Key Spec Table

CAS #EC NumberHill FormulaChemical FormulaMolar Mass
1185-53-1214-684-5C₄H₁₁NO₃˙ ClHC₄H₁₁NO₃*ClH157.60 g/mol

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      Description
      Catalogue Number108219
      SynonymsTrometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
      DescriptionTris(hydroxymethyl)aminomethane hydrochloride
      References
      Product Information
      CAS number1185-53-1
      EC number214-684-5
      Hill FormulaC₄H₁₁NO₃˙ ClH
      Chemical formulaC₄H₁₁NO₃*ClH
      Molar Mass157.60 g/mol
      HS Code2922 19 99
      Structure formula ImageStructure formula Image
      Quality LevelMQ500
      Applications
      Biological Information
      Physicochemical Information
      Density1.28 g/cm3 (20.2 °C)
      Melting Point150.7 °C
      pH value4.2 (100 g/l, H₂O, 20 °C)
      Vapor pressure<0.1 hPa (50 °C)
      Solubility561 g/l soluble
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Storage class10 - 13 Other liquids and solids
      WGKWGK 1 slightly hazardous to water
      Disposal3
      Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      StorageStore at +15°C to +25°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Appearancewhite to almost white, crystalline powder
      Assay (alkalimetric, calculated on dried substance)≥ 99.0 %
      Identity (IR-spectrum)conforms
      pH-value (0.5 mol/l, water)3.5 - 5.0
      Melting point147 - 153 °C
      UV-Absorption (230 nm; 10 %; 1 cm; water)≤ 0.1
      UV-Absorption (260 nm; 10 %, 1 cm; water)≤ 0.06
      UV-Absorption (280 nm; 10 %; 1 cm; water)≤ 0.06
      UV-Absorption (300 nm; 10 %; 1 cm; water)≤ 0.02
      UV-Absorption (400 nm; 10 %; 1 cm; water)≤ 0.01
      Residual solvents (ICHQ3C) of class 2 (Methanol)≤ 3000 ppm
      Residual solvents (ICHQ3C) of class 2 (Nitromethane)≤ 50 ppm
      Residual solvents (ICHQ3C) of class 3 (Ethanol)≤ 5000 ppm
      Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)≤ 5000 ppm
      Other residual solvents (ICH Q3C)excluded by manufacturing process
      Sulfated ash≤ 0.03
      Loss on Drying (105°C)≤ 0.5
      Endotoxins< 2.5
      Total aerobic microbial count≤ 10²
      Total yeast and mould count
      ≤ 10²
      Salmonella spp.
      absent in 10 g
      E.coli
      absent in 1 g
      Staphylococcus aureus
      absent in 1 g
      Pseudomonas aeruginosa
      absent in 1 g
      Candida albicans
      absent in 1 g
      Bile tolerante gram negative bacteria
      absent in 1 g
      DNases (Exo- and endonucleases)
      not detected
      Proteases
      not detected
      RNases
      not detected
      Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
      Total yeast and mould count
      ≤ 10²
      Salmonella spp.
      absent in 10 g
      E.coli
      absent in 1 g
      Staphylococcus aureus
      absent in 1 g
      Pseudomonas aeruginosa
      absent in 1 g
      Candida albicans
      absent in 1 g
      Bile tolerante gram negative bacteria
      absent in 1 g
      DNases (Exo- and endonucleases)
      not detected
      Proteases
      not detected
      RNases
      not detected
      Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
      Global Trade Item Number
      Catalogue Number GTIN
      1082191000 04022536101811

      Documentation

      Material Qualification Dossier

      TitleVersion
      6.0

      Quality Management Dossier (Open Access)

      Title

      Operational Excellence Dossier

      Title

      Tris(hydroxymethyl)aminomethane hydrochloride SDS

      Title

      Safety Data Sheet (SDS) 

      Tris(hydroxymethyl)aminomethane hydrochloride Certificates of Analysis

      Product Number PackagingSpecificationLot Number
      1082191000 Plastic bottlePDF Specification Document

      Certificates

      Title