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612200 Tissue Plasminogen Activator, Human

Tissue Plasminogen Activator, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: tPA

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612200
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Overview

Replacement Information

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612200-1MG
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      		 Glass bottle 1 mg
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      Description
      OverviewNative tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acids. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration.
      Catalogue Number612200
      Brand Family Calbiochem®
      SynonymstPA
      References
      ReferencesKim, Y.H., et al. 1999. Science 284, 647.
      Tsirka, S.E., et al. 1995. Nature 377, 340.
      Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.
      Product Information
      FormLyophilized
      FormulationLyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween®-80 Detergent.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      SourcePrepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥300 KU/mg protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      612200-1MG 04055977187755

      Documentation

      Tissue Plasminogen Activator, Human SDS

      Title

      Safety Data Sheet (SDS) 

      Tissue Plasminogen Activator, Human Certificates of Analysis

      TitleLot Number
      612200

      References

      Reference overview
      Kim, Y.H., et al. 1999. Science 284, 647.
      Tsirka, S.E., et al. 1995. Nature 377, 340.
      Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-May-2011 JSW
      SynonymstPA
      DescriptionNative tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acid residues. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration. Dihydropyridine Ca2+ antagonist may increase levels of tPA.
      FormLyophilized
      FormulationLyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween®-80 Detergent.
      SourcePrepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥95% by SDS-PAGE
      Specific activity≥300 KU/mg protein
      SolubilityReconstitute with diH₂O to a final concentration of 1 mg/ml (e.g., 100 µg should be reconstituted in 100 µl).
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim, Y.H., et al. 1999. Science 284, 647.
      Tsirka, S.E., et al. 1995. Nature 377, 340.
      Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.