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605195 Thrombin, Human Plasma, High Activity

Thrombin, Human Plasma, High Activity MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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605195
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Overview

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605195-100U
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      Description
      OverviewDesigned for use in thrombin clotting time tests. Key enzyme that activates factor XIII and converts fibrinogen into fibrin.
      Catalogue Number605195
      Brand Family Calbiochem®
      References
      ReferencesForsberg, G., et al. 1992. J. Protein Chem. 11, 201.
      Garcia, J.G. 1992. J. Lab. Clin. Med. 120, 513.
      Scarborough, R.M., et al. 1992. J. Biol. Chem. 267, 13146.
      Weigel, L.M., et al. 1992. Infect. Immun. 60, 1568.
      Product Information
      CAS number9002-04-4
      Unit of DefinitionOne unit is determined by comparison with a standard curve prepared using the Bureau of Biologics standard thrombin.
      FormLyophilized solid
      FormulationLyophilized from 200 mM NaCl, 50 mM sodium citrate, 0.1% PEG-8000, pH 6.5.
      Quality LevelMQ100
      Applications
      Biological Information
      PurityComplete activation from homogeneous prothrombin by SDS-PAGE
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥2800 NIH units/mg protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXO8950000
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      605195-100U 04055977188400

      Documentation

      Thrombin, Human Plasma, High Activity SDS

      Title

      Safety Data Sheet (SDS) 

      Thrombin, Human Plasma, High Activity Certificates of Analysis

      TitleLot Number
      605195

      References

      Reference overview
      Forsberg, G., et al. 1992. J. Protein Chem. 11, 201.
      Garcia, J.G. 1992. J. Lab. Clin. Med. 120, 513.
      Scarborough, R.M., et al. 1992. J. Biol. Chem. 267, 13146.
      Weigel, L.M., et al. 1992. Infect. Immun. 60, 1568.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2008 RFH
      DescriptionDesigned for use in thrombin clotting time tests. Serine protease formed in the plasma during the clotting process from prothrombin, calcium, and thromboplasmin. Acts on the soluble plasma protein fibrinogen to convert it to an insoluble fibrin clot. Prepared from homogenous human prothrombin by activation with Factor Xa, Factor Va, and phospholipid. Designed for use in thrombin time tests.
      FormLyophilized solid
      FormulationLyophilized from 200 mM NaCl, 50 mM sodium citrate, 0.1% PEG-8000, pH 6.5.
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      CAS number9002-04-4
      RTECSXO8950000
      PurityComplete activation from homogeneous prothrombin by SDS-PAGE
      Specific activity≥2800 NIH units/mg protein
      Unit definitionOne unit is determined by comparison with a standard curve prepared using the Bureau of Biologics standard thrombin.
      SolubilityH₂O (1 mg/ml). Solution will have a cloudy appearance.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 9383
      ReferencesForsberg, G., et al. 1992. J. Protein Chem. 11, 201.
      Garcia, J.G. 1992. J. Lab. Clin. Med. 120, 513.
      Scarborough, R.M., et al. 1992. J. Biol. Chem. 267, 13146.
      Weigel, L.M., et al. 1992. Infect. Immun. 60, 1568.