572630 Sigma-AldrichSU5402 - CAS 215543-92-3 - Calbiochem
SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC₅₀ = 10-20 µM in the presence of 1 mM ATP).
More>> SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC₅₀ = 10-20 µM in the presence of 1 mM ATP). Less<<SU5402 - CAS 215543-92-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 215543-92-3 | C₁₇H₁₆N₂O₃ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 572630-1MG |
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Plastic ampoule | 1 mg |
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| 572630-2MG |
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Glass bottle | 2 mg |
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| Description | |
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| Overview | A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available. |
| Catalogue Number | 572630 |
| Brand Family | Calbiochem® |
| Synonyms | 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone |
| References | |
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| References | Mohammadi, M., et al. 1997. Science 276, 955. |
| Product Information | |
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| CAS number | 215543-92-3 |
| ATP Competitive | Y |
| Declaration | Not available for sale in the United States. |
| Form | Lyophilized solid |
| Hill Formula | C₁₇H₁₆N₂O₃ |
| Chemical formula | C₁₇H₁₆N₂O₃ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ200 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 572630-1MG | 04055977266207 |
| 572630-2MG | 04055977266238 |
Documentation
SU5402 - CAS 215543-92-3 - Calbiochem SDS
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SU5402 - CAS 215543-92-3 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 572630 |
References
| Reference overview |
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| Mohammadi, M., et al. 1997. Science 276, 955. |
Citations
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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