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553210 Rapamycin - CAS 53123-88-9 - Calbiochem

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Rapamycin - CAS 53123-88-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: mTOR Inhibitor I

Primary Target: Mammalian target of rapamycin (mTOR)
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553210
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
53123-88-9C₅₁H₇₉NO₁₃

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553210-100UG
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      553210-1MG
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          553210-5MG
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              		 Glass bottle 5 mg
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              Description
              OverviewAnti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
              Catalogue Number553210
              Brand Family Calbiochem®
              SynonymsmTOR Inhibitor I
              References
              ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
              Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
              Braun, W., et al. 1995. FASEB J. 9, 63.
              Nielsen, F.C., et al. 1995. Nature 377, 358.
              Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
              Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
              Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
              Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
              Kuo, J., et al. 1992. Nature 358, 70.
              Price, D.J., et al. 1992. Science 257, 973.
              Heitman, J., et al. 1991. Science 253, 905.
              Kay, J.E., et al. 1991. Immunology 72, 544.
              Schreiber, S.L. 1991. Science 251, 283.
              Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
              Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
              Product Information
              CAS number53123-88-9
              ATP CompetitiveN
              FormClear film
              Hill FormulaC₅₁H₇₉NO₁₃
              Chemical formulaC₅₁H₇₉NO₁₃
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              Biological Information
              Primary TargetMammalian target of rapamycin (mTOR)
              Primary Target IC<sub>50</sub>50 pM against p70 S6 kinase
              Purity≥99% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSVE6250000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Catalogue Number GTIN
              553210-100UG 04055977193510
              553210-1MG 04055977193480
              553210-5MG 04055977193534

              Documentation

              Rapamycin - CAS 53123-88-9 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Rapamycin - CAS 53123-88-9 - Calbiochem Certificates of Analysis

              TitleLot Number
              553210

              References

              Reference overview
              Chen, T., et al. 2011. Aging Cell. 10, 908.
              Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
              Braun, W., et al. 1995. FASEB J. 9, 63.
              Nielsen, F.C., et al. 1995. Nature 377, 358.
              Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
              Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
              Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
              Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
              Kuo, J., et al. 1992. Nature 358, 70.
              Price, D.J., et al. 1992. Science 257, 973.
              Heitman, J., et al. 1991. Science 253, 905.
              Kay, J.E., et al. 1991. Immunology 72, 544.
              Schreiber, S.L. 1991. Science 251, 283.
              Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
              Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

              Brochure

              Title
              Bulk Product Guide
              Caspases and other Apoptosis Related Tools Brochure

              Data Sheet

              Title
              Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

              Posters

              Title
              Human Kinome & InhibitorSelect™ Libraries

              Citations

              Title
            • Chen, T., et al. 2011. Aging Cell. 10, 908.
            • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
            • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
            • Liao, X., et al. 2003. Endocrinology 144, 1656.
              		•
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision11-September-2014 JSW
              SynonymsmTOR Inhibitor I
              DescriptionSelectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
              FormClear film
              CAS number53123-88-9
              RTECSVE6250000
              Chemical formulaC₅₁H₇₉NO₁₃
              Structure formulaStructure formula
              Purity≥99% by HPLC
              SolubilityDMSO (200 mg/ml) or Ethanol (50 mg/ml)
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              Merck USA index14, 8114
              ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
              Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
              Braun, W., et al. 1995. FASEB J. 9, 63.
              Nielsen, F.C., et al. 1995. Nature 377, 358.
              Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
              Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
              Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
              Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
              Kuo, J., et al. 1992. Nature 358, 70.
              Price, D.J., et al. 1992. Science 257, 973.
              Heitman, J., et al. 1991. Science 253, 905.
              Kay, J.E., et al. 1991. Immunology 72, 544.
              Schreiber, S.L. 1991. Science 251, 283.
              Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
              Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
              Citation
            • Chen, T., et al. 2011. Aging Cell. 10, 908.
            • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
            • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
            • Liao, X., et al. 2003. Endocrinology 144, 1656.
              		•