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SCM075 Sigma-AldrichROCK Inhibitor (Y-27632)

The ROCK Inhibitor (Y-27632) is available in a 5 mg format & has been optimized & validated for cell culture & Neuroscience applications.

ROCK Inhibitor (Y-27632) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
Brochures

Key Applications: Cell Culture, Neuroscience

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SCM075

5 mg

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Overview

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Key Spec Table

Key Applications
CULT, Neuroscience

Description
Catalogue Number	SCM075
Description	ROCK Inhibitor (Y-27632)
Background Information	ROCK Inhibitor (Y-27632) is a selective, ATP-competitive inhibitor of Rho-associated protein kinase (ROCK) including p160Rock (Ki=140nM) and Rock-II. Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. One-hour treatment with 10uM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells (hESCs), increases survival and cloning efficiency of hESCs without affecting their pluripotency1. Recently, some reports showed that the application of Y-27632 and Accutase (Cat. No. SCR005), a formulated mixture of digestive enzymes, enhances the post-thaw survival rate of single hESCs using conventional slow freezing and rapid thawing methods

References

Product Information
HS Code	2933 39 99
Quality Level	MQ100

Applications
Application	The ROCK Inhibitor (Y-27632) is available in a 5 mg format & has been optimized & validated for cell culture & Neuroscience applications.
Key Applications	Cell Culture Neuroscience

Biological Information
Media Form	Liquid
Molecular Weight	320.26 g/mol

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Before Reconstitution: Maintain at -20ºC, protected from light for 2 years. After Reconstitution: 1 year at -20ºC, protected from light

Packaging Information
Material Size	5 mg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
SCM075	04053252374654

Documentation

ROCK Inhibitor (Y-27632) SDS

Title
Safety Data Sheet (SDS)

ROCK Inhibitor (Y-27632) Certificates of Analysis

Title	Lot Number
ROCK Inhibitor (Y-27632) 5 mg	2975574
ROCK Inhibitor (Y-27632) 5 mg	2934776
ROCK Inhibitor (Y-27632) 5 mg	3091588
ROCK Inhibitor (Y-27632) 5 mg	2829752
ROCK Inhibitor (Y-27632) 5 mg - 2427507	2427507
ROCK Inhibitor (Y-27632) 5 mg - 2053029	2053029
ROCK Inhibitor (Y-27632) 5 mg - 2196069	2196069
ROCK Inhibitor (Y-27632) 5 mg - 2325726	2325726
ROCK Inhibitor (Y-27632) 5 mg - 3236527	3236527
ROCK Inhibitor (Y-27632) 5 mg - 3287863	3287863

Brochure

Title
Human Stem Cell Systems

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