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108975 Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
103476-89-7C₂₀H₃₈N₆O₄ . 1/2H₂SO₄

Pricing & Availability

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108975-100MG
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      108975-10MG
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          108975-25MG
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              108975-5MG
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                  Description
                  OverviewA reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV+ donors. Also available as a 50 mM solution in H2O (Cat. No. 509281).
                  Catalogue Number108975
                  Brand Family Calbiochem®
                  SynonymsAc-LLR-CHO, ½H₂SO₄
                  References
                  ReferencesMontenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
                  Sarin, A., et al. 1994. J. Immunol. 153, 862.
                  Product Information
                  CAS number103476-89-7
                  ATP CompetitiveN
                  FormWhite lyophilized solid
                  Hill FormulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
                  Chemical formulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
                  Hygroscopic Hygroscopic
                  ReversibleY
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ200
                  Applications
                  Biological Information
                  Primary Targettrypsin- and cysteine-like proteases
                  Purity≥90% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Peptide SequenceAc-Leu-Leu-arginal, hemisulfate
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage -20°C
                  Hygroscopic Hygroscopic
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications
                  Global Trade Item Number
                  Catalogue Number GTIN
                  108975-100MG 04055977208535
                  108975-10MG 04055977208528
                  108975-25MG 07790788047757
                  108975-5MG 04055977208573

                  Documentation

                  Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem Certificates of Analysis

                  TitleLot Number
                  108975

                  References

                  Reference overview
                  Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
                  Sarin, A., et al. 1994. J. Immunol. 153, 862.

                  Brochure

                  Title
                  Bulk Product Guide
                  Caspases and other Apoptosis Related Tools Brochure

                  Citations

                  Title
                • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision29-March-2010 JSW
                  SynonymsAc-LLR-CHO, ½H₂SO₄
                  DescriptionA reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV+ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.
                  FormWhite lyophilized solid
                  CAS number103476-89-7
                  Chemical formulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
                  Peptide SequenceAc-Leu-Leu-arginal, hemisulfate
                  Structure formulaStructure formula
                  Purity≥90% by HPLC
                  SolubilityH₂O (50 mg/ml)
                  Storage -20°C
                  Hygroscopic
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
                  Toxicity Standard Handling
                  Merck USA index14, 5456
                  ReferencesMontenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
                  Sarin, A., et al. 1994. J. Immunol. 153, 862.
                  Citation
                • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.