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100129 L-Aspartic acid

Overview

Replacement Information

Key Spec Table

CAS #EC NumberHill FormulaMolar MassGrade Value
56-84-8200-291-6C₄H₇NO₄133.10 g/molPh Eur,BP,ChP,JP,USP

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      Description
      Catalogue Number100129
      SynonymsL-a-Aminosuccinic acid, L-αlpha-Aminosuccinic acid, Asp
      References
      Product Information
      CAS number56-84-8
      EC number200-291-6
      GradePh Eur,BP,ChP,JP,USP
      Hill FormulaC₄H₇NO₄
      Molar Mass133.10 g/mol
      HS Code2922 49 85
      Structure formula ImageStructure formula Image
      Quality LevelMQ500
      Applications
      Biological Information
      Physicochemical Information
      Density1.66 g/cm3 (13 °C)
      Melting Point230 °C (decomposition)
      pH value3.03 (10 g/l, H₂O)
      Bulk density430 kg/m3
      Solubility4 g/l
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Storage class10 - 13 Other liquids and solids
      WGKWGK 1 slightly hazardous to water
      Disposal3
      Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      StorageStore at +2°C to +30°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Assay (alkalimetric, calculated on dried substance)98.5 - 101.0 %
      Identity (IR-spectrum)passes test
      Identity (enantiomeric purity)passes test
      Identity (TLC)passes test
      Appearancewhite to almost white, crystalline powder or colorless crystals
      Appearance of solution (50 g/l; hydrochloric acid 1 mol/l)clear and not more intense in color than reference solution BY₆
      Transmittance of solution (100 g/l, hydrochloric acid 1 mol/l)≥ 98.0 %
      Spec. rotation (α 20/D, 80 g/l, hydrochloric acid 6 mol/l, calc. on dried substance)+24.0 to +26.0
      pH (4 g/l CO2-free water)2.5 - 3.5
      Acidity (5 g/l, water)2.0 - 4.0
      Chloride (Cl)≤ 200 ppm
      Sulfate (SO₄)≤ 200 ppm
      Heavy metals (as Pb)≤ 10 ppm
      Iron (Fe)≤ 10 ppm
      As (Arsenic)≤ 1 ppm
      Enantiomeric purity (HPLC) (D-aspartic acid)≤ 0.3 %
      Dicarboxylic acids (HPLC) (malic acid)≤ 0.2 %
      Dicarboxylic acids (HPLC) (fumaric acid)≤ 0.10 %
      Dicarboxylic acids (HPLC) (maleic acid)≤ 0.10 %
      Dicarboxylic acids (HPLC) (any unspecified impurity)≤ 0.10 %
      Dicarboxylic acids (HPLC) (total unspecified impurities)≤ 0.3 %
      Related compounds (HPLC) (maleic acid)≤ 0.05 %
      Related compounds (HPLC) (malic acid)≤ 0.20 %
      Related compounds (HPLC) (fumaric acid)≤ 0.10 %
      Related compounds (HPLC) (Any unspecified impurity)≤ 0.05 %
      Related compounds (HPLC) (Total unspecified impurities)≤ 0.10 %
      Ninhydrin-positive substances (LC)(impurity C (glutamic acid))≤ 0.2 %
      Ninhydrin-positive substances (LC)(impurity D (alanine))≤ 0.2 %
      Ninhydrin-positive substances (LC)(impurity G (asparagine))≤ 0.2 %
      Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity)≤ 0.10 %
      Ninhydrin-positive substances (LC) (total impurities)≤ 1.0 %
      Ninhydrin-positive substances (LC) (ammonium (570 nm))≤ 0.02 %
      Other amino acids (TLC)≤ 0.5 %
      Related substances (TLC)passes test
      Residual solvents (ICH Q3C)excluded by manufacturing process
      Sulfated ash (600 °C)≤ 0.1 %
      Loss on drying (105 °C; 3 h)≤ 0.20 %
      Bacterial endotoxins≤ 25 I.U./g
      Microbiological test (total aerobic microbial count (TAMC))≤ 10²
      Microbiological test (total yeast and mould count (TYMC))≤ 10²
      Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
      Compliance with pyrogens (according to ChP) is guaranteed by the test for bacterial endotoxins (ChP) and the production process.
      Corresponds to Ph. Eur., BP, ChP, JP, USP.
      Global Trade Item Number
      Catalogue Number GTIN
      1001291000 04022536002194

      Documentation

      Material Qualification Dossier

      TitleVersion
      9.0

      Quality Management Dossier (Open Access)

      Title

      Operational Excellence Dossier

      Title

      L-Aspartic acid SDS

      Title

      Safety Data Sheet (SDS) 

      L-Aspartic acid Certificates of Analysis

      Product Number PackagingSpecificationLot Number
      1001291000 Plastic bottlePDF Specification Document

      Certificates

      Title