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407652 Interleukin-6, Human, Recombinant, E. coli

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: rhIL-6

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407652
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Overview

Replacement Information

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407652-10UG
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      		 Plastic ampoule 10 μg
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      Description
      OverviewRecombinant, human, interleukin-6 expressed in E. coli. A prototypic pleiotrophic, pro-inflammatory cytokine that stimulates the production of acute phase proteins by hepatocytes. Also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B cells, T cells, and hepatocytes. Stimulates growth and inhibits constitutive, protein synthesis-independent apoptosis of murine B cell hybridoma 7TD1. IL-6 is produced by macrophages, endothelial cells, and activated T helper cells. Also considered as a potential marker of adipocyte differentiation. Human IL-6 is active on murine cells.
      Catalogue Number407652
      Brand Family Calbiochem®
      SynonymsrhIL-6
      References
      ReferencesVicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9.
      Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890.
      Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
      Liu, J., et al. 1994. Cell Immunol. 155, 229.
      Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.
      Product Information
      FormLyophilized
      FormulationCarrier free.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activity8-20 pg/ml as measured in a cell proliferation assay with a factor-dependent murine plasmacytoma cell line, B9.
      Purity≥95% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤1.0 EU/µg IL-6
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407652-10UG 04055977211405

      Documentation

      Interleukin-6, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-6, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      407652

      References

      Reference overview
      Vicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9.
      Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890.
      Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
      Liu, J., et al. 1994. Cell Immunol. 155, 229.
      Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-October-2007 JSW
      SynonymsrhIL-6
      DescriptionRecombinant, human, interleukin-6 expressed in E. coli. Interleukin-6 is a protein produced by a number of cell types including T-lymphocytes, monocytes, diploid fibroblasts, hepatocytes, cardiac myxomas, certain cervical cancer cells, bladder cell carcinomas, vascular endothelial cells, and human myelomas. It has a variety of biological effects and does not show a high degree of species specificity. Stimulates the production of acute phase proteins by hepatocytes. Also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B-cells, T-cells, and hepatocytes. Stimulates growth and inhibits constitutive protein synthesis-independent apoptosis of murine B-cell hybridoma 7TD1. Human sequence IL-6 is active on murine cells. 1 µg is equivalent to 7.0 x 103 WHO units.
      FormLyophilized
      FormulationCarrier free.
      Purity≥95% by SDS-PAGE
      ContaminantsEndotoxin: ≤1.0 EU/µg IL-6
      Biological activity8-20 pg/ml as measured in a cell proliferation assay with a factor-dependent murine plasmacytoma cell line, B9.
      SolubilityReconstitute to 0.1-1.0 mg/ml in 100 mM acetic acid.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesVicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9.
      Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890.
      Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
      Liu, J., et al. 1994. Cell Immunol. 155, 229.
      Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.