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345834 Genistein, Soybean - CAS 446-72-0 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
446-72-0C₁₅H₁₀O₅

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345834-20MG
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      Glass bottle 20 mg
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      Description
      OverviewA cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC50 > 350 µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro.
      Catalogue Number345834
      Brand Family Calbiochem®
      Synonyms4ʹ,5,7-Trihydroxyisoflavone
      References
      ReferencesConstantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
      Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
      Wei, H., et al. 1995. Carcinogenesis 17, 73.
      Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
      Migita, K., et al. 1994. J. Immunol. 153, 3457.
      Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
      Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
      Hill, T.D., et al. 1990. Science 248, 1660.
      Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
      Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
      Product Information
      CAS number446-72-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₁₀O₅
      Chemical formulaC₁₅H₁₀O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetEGFR kinase
      Primary Target IC<sub>50</sub>2.6 µM against autophosphorylation of epidermal growth factor receptor kinase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSNR2392000
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      345834-20MG 04055977214376