Millipore Sigma Vibrant Logo

05-23-3800 Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ET-1, CSCSSLMDKECVYFCHLDIIW

Primary Target: Potent vasoconstrictive action
View Products on Sigmaaldrich.com
05-23-3800
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
117399-94-7C₁₀₉H₁₅₉N₂₅O₃₂S₅

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
US105233800-0.5MG
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule .5 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewA 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
      Catalogue Number05-23-3800
      Brand Family Calbiochem®
      SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
      References
      ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
      Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
      Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
      Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
      Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
      Yanagisawa, M., et al. 1988. Nature 332, 411.
      Product Information
      CAS number117399-94-7
      ATP CompetitiveN
      FormWhite to off-white solid
      FormulationSupplied as an acetate salt.
      Hill FormulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
      Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPotent vasoconstrictive action
      Purity≥96% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide ContentY
      Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      US105233800-0.5MG 04055977226782

      Documentation

      Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      05-23-3800

      References

      Reference overview
      Cesari, M., et al. 1996. Am. Heart J. 132, 1236.
      Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
      Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
      Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
      Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
      Yanagisawa, M., et al. 1988. Nature 332, 411.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-May-2008 JSW
      SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
      DescriptionA 21 amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
      FormWhite to off-white solid
      FormulationSupplied as an acetate salt.
      CAS number117399-94-7
      Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
      Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
      Purity≥96% by HPLC
      Solubility5% Acetic acid (0.5 mg/ml). Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with distilled water to achieve 5% acetic acid and 0.5 mg/ml peptide.
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Toxicity Standard Handling
      ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
      Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
      Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
      Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
      Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
      Yanagisawa, M., et al. 1988. Nature 332, 411.