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05-23-3800 Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ET-1, CSCSSLMDKECVYFCHLDIIW

Primary Target: Potent vasoconstrictive action
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05-23-3800
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Overview

Key Spec Table

CAS #Empirical Formula
117399-94-7C₁₀₉H₁₅₉N₂₅O₃₂S₅

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      Description
      OverviewA 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
      Catalogue Number05-23-3800
      Brand Family Calbiochem®
      SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
      References
      ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
      Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
      Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
      Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
      Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
      Yanagisawa, M., et al. 1988. Nature 332, 411.
      Product Information
      CAS number117399-94-7
      ATP CompetitiveN
      FormWhite to off-white solid
      FormulationSupplied as an acetate salt.
      Hill FormulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
      Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Biological Information
      Primary TargetPotent vasoconstrictive action
      Purity≥96% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide ContentY
      Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      US105233800-0.5MG 04055977226782