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250255 Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem

Cytochalasin D, Zygosporium mansonii, CAS 22144-77-0, is a fungal toxin that is about 10-fold more potent than cytochalasin B in inhibiting actin filament function. Blocks cytoplasmic division.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Actin filament function
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250255
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
22144-77-0C₃₀H₃₇NO₆

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      Description
      OverviewCell-permeable fungal toxin. About 10-fold more potent than cytochalasin B in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inactivates low conductance K+ channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca2+ levels. Exhibits antitumor activity. Also available as a 10 mM solution in DMSO (Cat. No. 504776).
      Catalogue Number250255
      Brand Family Calbiochem®
      References
      ReferencesSasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
      Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
      Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
      Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
      Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
      Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
      Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
      Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.
      Product Information
      CAS number22144-77-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₀H₃₇NO₆
      Chemical formulaC₃₀H₃₇NO₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetActin filament function
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGZ4850000
      Safety Information
      R PhraseR: 26/27/28-61

      Very toxic by inhalation, in contact with skin and if swallowed.
      May cause harm to the unborn child.
      S PhraseS: 3/7/9-22-36/37/39-45

      Keep container tightly closed, in a cool well ventilated place.
      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in chloroform, aliquot, dry under a stream of nitrogen, and freeze (-20°C). Reconstitute in DMSO just prior to use. Dried aliquots are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      250255-1MG 07790788048952

      Documentation

      Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      250255

      References

      Reference overview
      Sasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
      Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
      Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
      Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
      Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
      Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
      Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
      Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.

      Citations

      Title
    • Jessica A. Gorski, et al. (2005) Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Molecular Biology of the Cell 16, 3574-3590.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2008 RFH
      DescriptionA cell-permeable fungal toxin that is approximately 10 times more potent than cytochalasin B in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments at 10 µM. Inactivates low conductance K+ channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca2+ levels. Cytochalasin D also exhibits antibiotic and anti-tumor activity.
      FormWhite solid
      CAS number22144-77-0
      RTECSGZ4850000
      Chemical formulaC₃₀H₃₇NO₆
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (2 mg/ml) or Chloroform (2 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in chloroform, aliquot, dry under a stream of nitrogen, and freeze (-20°C). Reconstitute in DMSO just prior to use. Dried aliquots are stable for up to 3 months at -20°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 2790
      ReferencesSasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
      Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
      Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
      Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
      Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
      Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
      Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
      Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.
      Citation
    • Jessica A. Gorski, et al. (2005) Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Molecular Biology of the Cell 16, 3574-3590.
      		•