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627610 Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem

Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-VAD (OMe)-FMK

Primary Target: Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells
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627610
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Overview

Key Spec Table

CAS #Empirical Formula
187389-52-2C₂₂H₃₀FN₃O₇

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      Description
      OverviewA cell-permeable, irreversible, pan-caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells. Shown to enhance the freeze-thaw survival of human embryonic stem cells. When using with purified native or recombinant enzyme, pre-treatment with an esterase is required.
      Catalogue Number627610
      Brand Family Calbiochem®
      SynonymsZ-VAD (OMe)-FMK
      References
      ReferencesHeng, B.C., et al. 2007. Biosci. Rep. 27, 257.
      Martin, U., et al. 2007. Apoptosis 12, 525.
      Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.
      Joo, C., et al. 1999. Ophthalmic Res. 31, 287.
      McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229.
      Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312.
      Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735.
      An, S. and Know, K.A. 1996. FEBS Lett. 386, 115.
      Cain, K., et al. 1996. Biochem J. 314, 27.
      Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266.
      Pronk, G.J., et al. 1996. Science 271, 808.
      Slee, E.A., et al. 1996. Biochem. J. 315, 21.
      Chow, S.C., et al. 1995. FEBS Lett. 364, 134.
      Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283.
      Zhu, H., et al. 1995. FEBS Lett. 374, 303.
      Product Information
      CAS number187389-52-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₂H₃₀FN₃O₇
      Chemical formulaC₂₂H₃₀FN₃O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetFas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells
      PuritySingle spot by TLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Val-Ala-Asp(OMe)-CH₂F*
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      627610-1MG 04055977262810