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215911 Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem

Carbonyl Cyanide m-Chlorophenylhydrazone, CAS 555-60-2, is a protonophore uncoupling agent for oxidative phosphorylation. Shown to be about 100-fold more effective than 2, 4-DNP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CCCP

Primary Target: cytochrome c oxydase
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215911
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Overview

Key Spec Table

CAS #
555-60-2

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215911-250MG
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      Description
      OverviewProtonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol. Binds with cytochrome c oxidase with high affinity (Kd = 270 nM). Inhibits transport processes and depresses growth.
      Catalogue Number215911
      Brand Family Calbiochem®
      SynonymsCCCP
      References
      ReferencesBona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
      Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun. 7, 272.
      Product Information
      CAS number555-60-2
      ATP CompetitiveN
      FormYellow solid
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCarbonyl Cyanide m-Chlorophenylhydrazone, CAS 555-60-2, is a protonophore uncoupling agent for oxidative phosphorylation. Shown to be about 100-fold more effective than 2, 4-DNP.
      Biological Information
      Primary Targetcytochrome c oxydase
      Primary Target IC<sub>50</sub>Kd = 270 nM in binding with cytochrome c oxidase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSFG5600000
      Safety Information
      R PhraseR: 20/21/22-36/37/38

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.
      Global Trade Item Number
      Catalogue Number GTIN
      215911-250MG 04055977219241