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03-34-0051 Calpeptin - CAS 117591-20-5 - Calbiochem

Calpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)

Calpeptin - CAS 117591-20-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Benzyloxycarbonylleucyl-norleucinal

Primary Target: Calpain-1
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03-34-0051
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
117591-20-5C₂₀H₃₀N₂O₄

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      		 Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
      Catalogue Number03-34-0051
      Brand Family Calbiochem®
      SynonymsBenzyloxycarbonylleucyl-norleucinal
      References
      ReferencesLee, M.S., et al. 2000. Nature 405, 360.
      Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
      Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
      Shiba, E., et al. 1996. Anticancer Res. 16, 773.
      Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
      Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
      Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
      Product Information
      CAS number117591-20-5
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₀H₃₀N₂O₄
      Chemical formulaC₂₀H₃₀N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCalpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)
      Biological Information
      Primary TargetCalpain-1
      Primary Target IC<sub>50</sub>ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
      Purity≥94% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Nle-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      03-34-0051-5MG 04055977206852

      Documentation

      Calpeptin - CAS 117591-20-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Calpeptin - CAS 117591-20-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      03-34-0051

      References

      Reference overview
      Lee, M.S., et al. 2000. Nature 405, 360.
      Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
      Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
      Shiba, E., et al. 1996. Anticancer Res. 16, 773.
      Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
      Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
      Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

      Citations

      Title
    • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
    • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-October-2007 JSW
      SynonymsBenzyloxycarbonylleucyl-norleucinal
      DescriptionA cell-permeable calpain inhibitor. Inactivates calpain I (ID50 = 52 nM), calpain II (ID50 = 34 nM), and papain (ID50 = 138 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number117591-20-5
      Chemical formulaC₂₀H₃₀N₂O₄
      Peptide SequenceZ-Leu-Nle-CHO
      Structure formulaStructure formula
      Purity≥94% by HPLC
      SolubilityDMF (5 mg/ml) or DMSO (5 mg/ml). Dissolve in a minimal amount of DMF or DMSO then add H₂O, buffer or medium just prior to use.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, M.S., et al. 2000. Nature 405, 360.
      Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
      Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
      Shiba, E., et al. 1996. Anticancer Res. 16, 773.
      Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
      Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
      Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
      Citation
    • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
    • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
      		•