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208694 Calmodulin, Bovine Brain, High Purity

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208694
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208694-1MG
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      Description
      OverviewA ubiquitous Ca2+-binding protein that serves as a physiological effector of a wide range of biological processes. Calmodulin highly purified from bovine brain.
      Note: this product cannot be used for animal treatment, in vivo research, or any contact procedure with livestock.
      Catalogue Number208694
      Brand Family Calbiochem®
      SynonymsCaM, Ca2+/Calmodulin
      References
      ReferencesBagchi, I.C., et al. 1992. J. Biol. Chem. 267, 3024.
      O'Neil, K.T., and DeGrado, W.F. 1990. Trends Pharmacol. Sci. 15, 59.
      Harrison, J.K., et al. 1988. J. Neurochem. 51, 345.
      Gopalakrishna, R., and Anderson, W.B. 1983. J. Biol. Chem. 258, 2405.
      Gopalakrishna, R., and Anderson, W.B. 1982. Biochem. Biophys. Res. Commun. 104, 830.
      Sharma, B.K., et al. 1979. Adv. Cyclic Nucleotide Res. 10, 187.
      Product Information
      CAS number73298-54-1
      Unit of DefinitionOne unit is defined as the amount of calmodulin that gives rise to 50% of the maximal enzyme activation of a standard level of activator-deficient calcineurin.
      FormLyophilized
      FormulationLyophilized from 30 mM HEPES, 1 mM CaCl₂, 0.1 mM DTT, pH 7.4.
      Sold on the basis of peptide contentY
      Quality LevelMQ200
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      Specific Activity≥250,000 units/mg protein
      Physicochemical Information
      Peptide ContentY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Aqueous stock solutions are stable for up to 2 months at -20°C or for up to 4 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      208694-1MG 04055977203325

      Documentation

      Calmodulin, Bovine Brain, High Purity SDS

      Title

      Safety Data Sheet (SDS) 

      Calmodulin, Bovine Brain, High Purity Certificates of Analysis

      TitleLot Number
      208694

      References

      Reference overview
      Bagchi, I.C., et al. 1992. J. Biol. Chem. 267, 3024.
      O'Neil, K.T., and DeGrado, W.F. 1990. Trends Pharmacol. Sci. 15, 59.
      Harrison, J.K., et al. 1988. J. Neurochem. 51, 345.
      Gopalakrishna, R., and Anderson, W.B. 1983. J. Biol. Chem. 258, 2405.
      Gopalakrishna, R., and Anderson, W.B. 1982. Biochem. Biophys. Res. Commun. 104, 830.
      Sharma, B.K., et al. 1979. Adv. Cyclic Nucleotide Res. 10, 187.

      Citations

      Title
    • Xinchun Shen, et al. (2005) Scanning the human proteome for calmodulin-binding proteins. Proceedings of the National Academy of Sciences (USA) 102, 5969-5974.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-February-2014 JSW
      SynonymsCaM, Ca2+/Calmodulin
      DescriptionA ubiquitous Ca2+-binding protein distributed in eukaryotic cells that serves as a major physiological effector for a wide range of cellular responses. The Ca2+-calmodulin complex is involved in the maintenance of intracellular Ca2+ homeostasis, as well as in the regulation of the intracellular concentration of other second messengers, such as cyclic AMP and inositol trisphosphate. Calmodulin highly purified from bovine brain.

      Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
      FormLyophilized
      FormulationLyophilized from 30 mM HEPES, 1 mM CaCl₂, 0.1 mM DTT, pH 7.4.
      CAS number73298-54-1
      Purity≥95% by SDS-PAGE
      Specific activity≥250,000 units/mg protein
      Unit definitionOne unit is defined as the amount of calmodulin that gives rise to 50% of the maximal enzyme activation of a standard level of activator-deficient calcineurin.
      SolubilityAqueous buffers or H₂O. Please refer to the vial label for lot-specific reconstitution volume.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Aqueous stock solutions are stable for up to 2 months at -20°C or for up to 4 months at -70°C.
      Toxicity Standard Handling
      Merck USA index14, 1719
      ReferencesBagchi, I.C., et al. 1992. J. Biol. Chem. 267, 3024.
      O'Neil, K.T., and DeGrado, W.F. 1990. Trends Pharmacol. Sci. 15, 59.
      Harrison, J.K., et al. 1988. J. Neurochem. 51, 345.
      Gopalakrishna, R., and Anderson, W.B. 1983. J. Biol. Chem. 258, 2405.
      Gopalakrishna, R., and Anderson, W.B. 1982. Biochem. Biophys. Res. Commun. 104, 830.
      Sharma, B.K., et al. 1979. Adv. Cyclic Nucleotide Res. 10, 187.
      Citation
    • Xinchun Shen, et al. (2005) Scanning the human proteome for calmodulin-binding proteins. Proceedings of the National Academy of Sciences (USA) 102, 5969-5974.