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220201 CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem

CAS 75621-03-3 is a zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate

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220201
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
75621-03-3C₃₂H₅₈N₂O₇S

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      220201-1GM
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              220201-5GM
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                  Description
                  OverviewZwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than structurally-related carboxylic acid anions and is much more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100 Detergent. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding of opiates. Also, capable of disaggregating cytochrome P450 to its monomeric form without denaturation. Has a small micellar molecular weight and a high critical micellar concentration and can be removed from either gels or protein solutions by dialysis across a membrane. Aggregation number: 4-14.
                  Conductivity (1.0 M, 24°C): <100 µmhos.
                  Catalogue Number220201
                  Brand Family Calbiochem®
                  Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
                  References
                  ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
                  Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                  Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                  Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                  Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                  Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                  Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.
                  Product Information
                  CAS number75621-03-3
                  Aggregation Number4 - 14
                  CMC6 - 10 mM
                  FormWhite crystalline powder
                  Hill FormulaC₃₂H₅₈N₂O₇S
                  Chemical formulaC₃₂H₅₈N₂O₇S
                  Hygroscopic Hygroscopic
                  Micellar weight6150
                  Quality LevelMQ300
                  Applications
                  Biological Information
                  Purity≥98% by NMR
                  Physicochemical Information
                  ContaminantsDNase, RNase, and Protease: none detected
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Safety Information
                  R PhraseR: 22-36/38

                  Harmful if swallowed.
                  Irritating to eyes and skin.
                  S PhraseS: 26-36

                  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                  Wear suitable protective clothing.
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Harmful
                  Storage +15°C to +30°C
                  Hygroscopic Hygroscopic
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications
                  Global Trade Item Number
                  Catalogue Number GTIN
                  220201-10GM 07790788048754
                  220201-1GM 04055977200973
                  220201-25GM 04055977201000
                  220201-5GM 04055977201024

                  Documentation

                  CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem SDS

                  Title

                  Safety Data Sheet (SDS) 

                  CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem Certificates of Analysis

                  TitleLot Number
                  220201

                  References

                  Reference overview
                  Chen, Y., et al. 1992. Biochemistry 31, 2415.
                  Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                  Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                  Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                  Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                  Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                  Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.

                  Brochure

                  Title
                  Biological Detergents Brochure
                  Bulk Product Guide
                  CALBIOSORBﾙ Technical Bulletin
                  Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision12-November-2010 RFH
                  Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
                  DescriptionNon-denaturing zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than the structurally related carboxylic acid anions, and is more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding to opiates. Also capable of disaggregating P 450 to its monomeric form without denaturation. Has a small micellar molecular weight (6150 Daltons) and a high critical micellar concentration (6-10 mM). Can be removed from either gels or protein solutions by dialysis. Aggregation number: 4-14.
                  FormWhite crystalline powder
                  CAS number75621-03-3
                  Chemical formulaC₃₂H₅₈N₂O₇S
                  Purity≥98% by NMR
                  ContaminantsDNase, RNase, and Protease: none detected
                  SolubilityH₂O (1.0 M)
                  Storage +15°C to +30°C
                  Hygroscopic
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
                  Toxicity Harmful
                  Merck USA index14, 2044
                  ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
                  Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                  Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                  Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                  Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                  Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                  Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.