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220201 CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem

CAS 75621-03-3 is a zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate

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Overview

Key Spec Table

CAS #Empirical Formula
75621-03-3C₃₂H₅₈N₂O₇S

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                  Description
                  OverviewZwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than structurally-related carboxylic acid anions and is much more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100 Detergent. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding of opiates. Also, capable of disaggregating cytochrome P450 to its monomeric form without denaturation. Has a small micellar molecular weight and a high critical micellar concentration and can be removed from either gels or protein solutions by dialysis across a membrane. Aggregation number: 4-14.
                  Conductivity (1.0 M, 24°C): <100 µmhos.
                  Catalogue Number220201
                  Brand Family Calbiochem®
                  Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
                  References
                  ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
                  Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                  Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                  Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                  Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                  Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                  Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.
                  Product Information
                  CAS number75621-03-3
                  Aggregation Number4 - 14
                  CMC6 - 10 mM
                  FormWhite crystalline powder
                  Hill FormulaC₃₂H₅₈N₂O₇S
                  Chemical formulaC₃₂H₅₈N₂O₇S
                  Hygroscopic Hygroscopic
                  Micellar weight6150
                  Quality LevelMQ300
                  Biological Information
                  Purity≥98% by NMR
                  Physicochemical Information
                  ContaminantsDNase, RNase, and Protease: none detected
                  Safety Information
                  R PhraseR: 22-36/38

                  Harmful if swallowed.
                  Irritating to eyes and skin.
                  S PhraseS: 26-36

                  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                  Wear suitable protective clothing.
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Harmful
                  Storage +15°C to +30°C
                  Hygroscopic Hygroscopic
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
                  Global Trade Item Number
                  Catalogue Number GTIN
                  220201-10GM 07790788048754
                  220201-1GM 04055977200973
                  220201-25GM 04055977201000
                  220201-5GM 04055977201024