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169756 Antithrombin III, Human Plasma - CAS 90170-80-2 - Calbiochem

Overview

Key Spec Table

CAS #
90170-80-2

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169756-1MG
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      Description
      OverviewSingle-chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.
      Catalogue Number169756
      Brand Family Calbiochem®
      SynonymsATIII, Heparin cofactor, Factor Xa inhibitor
      References
      ReferencesTsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.
      Product Information
      CAS number90170-80-2
      Unit of DefinitionOne unit is defined as the amount of antithrombin that will inhibit 1.0 unit of human plasma thrombin present in excess. Thrombin activity is measured using 500 µM tosyl-Gly-Pro-Arg-pNA as substrate in 100 mM Tris-HCl at 25°C, pH 8.2
      ATP CompetitiveN
      FormSolid
      FormulationLyophilized from 100 mM sodium citrate buffer, 20 mM Tris-HCl, pH 8.3.
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationAntithrombin III, Human Plasma, CAS 90170-80-2, is a single-chain glycoprotein that acts as a principal physiological inhibitor of thrombin.
      Biological Information
      Primary Targetthrombin
      Puritysingle band by SDS-PAGE
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥5 units/mg protein
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      169756-1MG 04055977207729