Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
.
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To begin designing your MILLIPLEX® MAP kit select a species, a panel type or kit of interest.
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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423500
Sigma-AldrichAnti-Klotho Rabbit pAb
This Anti-Klotho Rabbit pAb is validated for use in ELISA, Immunoblotting for the detection of Klotho.
More>>This Anti-Klotho Rabbit pAb is validated for use in ELISA, Immunoblotting for the detection of Klotho. Less<<
Anti-Klotho Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Inactivation mutation of the recently discovered klotho gene in mice causes a syndrome resembling aging. Homozygous mutant klotho (kl/kl) mice exhibit premature aging phenotypes such as osteoporosis, age related skin changes, ectopic calcification, atrophy of genital organs and thymus, atherosclerosis, emphysema, ataxia, and short life span. The kl gene encodes a membrane protein whose extracellular domain carries homology to β-glucosidases. There also exists a splice variant of kl mRNA that encodes a putative secreted protein in both human and mouse. kl gene expression was observed to be tissue specific. Improvement of systemic aging phenotypes in kl/kl mice occurs even when the exogenous expression was limited to some organs, suggesting that KL associated aging is regulated through a humoral signaling pathway.
Host
Rabbit
Immunogen species
Mouse
Immunogen
a synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of murine Klotho
Isotype
IgG
Species
mouse
Form
Liquid
Formulation
In PBS, 0.1% BSA, pH 7.5.
Concentration Label
Please refer to vial label for lot-specific concentration
Preservative
None
Comments
Variables associated with assay conditions will dictate the optimal working dilution.
Storage
Avoid freeze/thaw -20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-20°C).
Toxicity
Standard Handling
References
Kuro-o, M., et al. 1997. Nature390, 45. Martin, G.M. and Mian, I.S. 1997. Nature390, 18.
