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100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
52665-69-7C₂₉H₃₇N₃O₆

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
100105-1MG
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      100105-5MG
      Limited Availability
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      In Stock 
      Discontinued
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      Availability to be confirmed
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          Description
          OverviewA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
          Catalogue Number100105
          Brand Family Calbiochem®
          SynonymsCalcimycin
          References
          ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
          Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
          Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
          Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
          Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
          Product Information
          CAS number52665-69-7
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₉H₃₇N₃O₆
          Chemical formulaC₂₉H₃₇N₃O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Biological Information
          Primary TargetMitochondrial ATPase
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Safety Information according to GHS
          RTECSDM4676000
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Global Trade Item Number
          Catalogue Number GTIN
          100105-1MG 04055977226225
          100105-5MG 04055977226249