Millipore Sigma Vibrant Logo

100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem

A mobile ion-carrier that forms stable complexes with divalent cations.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Calcimycin

View Products on Sigmaaldrich.com
100105
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
52665-69-7C₂₉H₃₇N₃O₆

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
100105-1MG
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 1 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      100105-5MG
      Retrieving availability...
      —
      Limited Availability Limited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Plastic ampoule 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          Description
          OverviewA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
          Catalogue Number100105
          Brand Family Calbiochem®
          SynonymsCalcimycin
          References
          ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
          Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
          Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
          Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
          Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
          Product Information
          CAS number52665-69-7
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₉H₃₇N₃O₆
          Chemical formulaC₂₉H₃₇N₃O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetMitochondrial ATPase
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDM4676000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          100105-1MG 04055977226225
          100105-5MG 04055977226249

          Documentation

          A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          100105

          References

          Reference overview
          Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
          Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
          Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
          Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
          Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Tools and Tips for Analyzing Apoptosis
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          SynonymsCalcimycin
          DescriptionA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
          FormWhite solid
          CAS number52665-69-7
          RTECSDM4676000
          Chemical formulaC₂₉H₃₇N₃O₆
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO or Methanol. For use in aqueous systems, preparation of a 100 mM stock in DMSO is recommended. Microliter amounts of this solution can then be added to H₂O with rapid mixing (e.g. 10 µl into 5 ml of H₂O). In aqueous systems, the ionophore aggregates over time.
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 1639
          ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
          Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
          Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
          Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
          Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

          Related Products & Applications

          Alternative Products

          Catalogue Number Description  
          100106 A23187, Mixed Calcium-Magnesium Salt - CAS 52665-69-7 - Calbiochem Show Pricing & Availability
          100107 A23187, 4-Bromo- - CAS 76455-48-6 - Calbiochem Show Pricing & Availability

          Related Products

          Catalogue Number Description  
          407950 Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem Show Pricing & Availability

          Categories

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores