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554720 trans-Retinoic Acid - CAS 302-79-4 - Calbiochem

Potent modulator of growth and differentiation. Inhibits melanocyte adhesion, motility, and growth.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Tretinoin, ATRA, Vitamin A Acid

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554720
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CAS #Empirical Formula
302-79-4C₂₀H₂₈O₂

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554720-500MG
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      Description
      OverviewPotent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells. PROTECT FROM AIR.
      Catalogue Number554720
      Brand Family Calbiochem®
      SynonymsTretinoin, ATRA, Vitamin A Acid
      References
      ReferencesTosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
      Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
      Labbaye, C., et al. 1993. Blood 81, 475.
      Sakashita, A., et al. 1993. Blood 81, 1009.
      Situ, R., et al. 1993. Dermatology 186, 38.
      Tini, M., et al. 1993. Genes Develop. 7, 295.
      Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
      Sharpe, C.R. 1991. Neuron 7, 239.
      Thaller, C. and Eichele, G. 1990. Nature 345, 815.
      Product Information
      CAS number302-79-4
      FormYellow solid
      Hill FormulaC₂₀H₂₈O₂
      Chemical formulaC₂₀H₂₈O₂
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by assay
      Safety Information according to GHS
      RTECSVH6475000
      Safety Information
      R PhraseR: 22-36/37/38-63

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      Possible risk of harm to the unborn child.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 2 weeks at 4°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Numero di catalogo GTIN
      554720-500MG 04061838431332