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681640 Wee1 Inhibitor - CAS 622855-37-2 - Calbiochem

The Wee1 Inhibitor, also referenced under CAS 622855-37-2, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V

Primary Target: Wee1
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681640
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Tabella delle specifiche principali

CAS #Empirical Formula
622855-37-2C₂₀H₁₁ClN₂O₃

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681640-1MG
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      Description
      OverviewA pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 440 nM).
      Catalogue Number681640
      Brand Family Calbiochem®
      Synonyms4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V
      References
      ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
      Product Information
      CAS number622855-37-2
      ATP CompetitiveY
      FormLight orange solid
      Hill FormulaC₂₀H₁₁ClN₂O₃
      Chemical formulaC₂₀H₁₁ClN₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetWee1
      Primary Target IC<sub>50</sub>11 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      681640-1MG 04055977260182

      Documentation

      Wee1 Inhibitor - CAS 622855-37-2 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Wee1 Inhibitor - CAS 622855-37-2 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      681640

      Riferimenti bibliografici

      Panoramica delle referenze
      Palmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V
      DescriptionA pyrrolocarbazole compound that acts as a poten, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 440 nM).
      FormLight orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number622855-37-2
      Chemical formulaC₂₀H₁₁ClN₂O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.