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681636 W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl

Primary Target: mlck
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681636
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Tabella delle specifiche principali

CAS #Empirical Formula
88519-57-7C₁₄H₁₇ClN₂O₂S . HCl

Prezzi e disponibilità

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681636-1MG
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      Description
      OverviewA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM).
      Catalogue Number681636
      Brand Family Calbiochem®
      SynonymsN-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
      References
      ReferencesHidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
      Tanaka, T., et al. 1983. Pharmacol. 26, 249.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
      Product Information
      CAS number88519-57-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₄H₁₇ClN₂O₂S . HCl
      Chemical formulaC₁₄H₁₇ClN₂O₂S . HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetmlck
      Primary Target IC<sub>50</sub>58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase
      Purity≥98% by HPLC and single spot by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      681636-1MG 04055977260168

      Documentation

      W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      681636

      Riferimenti bibliografici

      Panoramica delle referenze
      Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
      Tanaka, T., et al. 1983. Pharmacol. 26, 249.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-January-2010 RFH
      SynonymsN-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
      DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM) and myosin light chain kinase (IC50 = 58 µM).
      FormWhite solid
      CAS number88519-57-7
      Chemical formulaC₁₄H₁₇ClN₂O₂S . HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC and single spot by TLC
      SolubilityH₂O (35 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Standard Handling
      ReferencesHidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
      Tanaka, T., et al. 1983. Pharmacol. 26, 249.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

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      Categorie

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors