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679101 Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem

CAS 32222-06-3 prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 1,25-(OH)₂-D₃, Calcitriol

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679101
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CAS #Empirical Formula
32222-06-3C₂₇H₄₄O₃

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      Description
      OverviewHas immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes. Regulates c-myc transcription. Induces reversible hydrolysis of sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Also available as a 1 mM solution in DMSO (Cat. No. 509721).
      Catalogue Number679101
      Brand Family Calbiochem®
      Synonyms1,25-(OH)₂-D₃, Calcitriol
      References
      ReferencesSemizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
      Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
      Mathieu, C., et al. 1994. Diabetologica 37, 552.
      Thomasset, M. 1994. Pathol. Biol. 42, 163.
      Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
      Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
      Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
      Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
      Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
      Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
      DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.
      Product Information
      CAS number32222-06-3
      FormSolid
      Hill FormulaC₂₇H₄₄O₃
      Chemical formulaC₂₇H₄₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Safety Information according to GHS
      RTECSFZ4645000
      Safety Information
      R PhraseR: 26/27/28-63

      Very toxic by inhalation, in contact with skin and if swallowed.
      Possible risk of harm to the unborn child.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Numero di catalogo GTIN
      679101-50UG 07790788052348