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586005 Thapsigargin - CAS 67526-95-8 - Calbiochem

Thapsigargin, CAS 67526-95-8, is a cell-permeable, tumor-promoting sesquiterpene lactone that releases calcium by non-competitvley inhibiting endoplasmic reticular Ca2+-ATPase (IC₅₀ = 4-13 nM).

Thapsigargin - CAS 67526-95-8 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: endoplasmic reticular Ca2+ ATPase
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586005
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
67526-95-8C₃₄H₅₀O₁₂

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586005-1MG
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      Description
      OverviewA cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4-13 nM). Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Induces apoptosis in rat thymocytes and in human hepatoma cells. Shown to induce apoptosis in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation.
      Catalogue Number586005
      Brand Family Calbiochem®
      References
      ReferencesJothi, M., et al. 2013. Mol. Cancer Ther. In press.
      Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
      Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
      Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
      Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
      Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
      Wong, W.L., et al. 1993. Biochem. J. 289, 71.
      Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
      Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
      Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
      Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.
      Product Information
      CAS number67526-95-8
      ATP CompetitiveN
      FormColorless solid
      Hill FormulaC₃₄H₅₀O₁₂
      Chemical formulaC₃₄H₅₀O₁₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary Targetendoplasmic reticular Ca2+ ATPase
      Primary Target IC<sub>50</sub>4-13 nM against endoplasmic reticular Ca2+-ATPase
      Purity≥97% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38-42

      Irritating to eyes, respiratory system and skin.
      May cause sensitization by inhalation.
      S PhraseS: 36/37/39-26

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2-3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      586005-1MG 04055977265026

      Documentation

      Thapsigargin - CAS 67526-95-8 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Thapsigargin - CAS 67526-95-8 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      586005

      Riferimenti bibliografici

      Panoramica delle referenze
      Jothi, M., et al. 2013. Mol. Cancer Ther. In press.
      Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
      Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
      Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
      Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
      Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
      Wong, W.L., et al. 1993. Biochem. J. 289, 71.
      Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
      Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
      Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
      Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.

      Brochure

      Titolo
      Caspases and other Apoptosis Related Tools Brochure
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2013 JSW
      DescriptionA cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase. Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Activates apoptosis in rat thymocytes and induces apoptosis in human hepatoma cells. Shown to induce apoptosis in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation.
      FormColorless solid
      CAS number67526-95-8
      Chemical formulaC₃₄H₅₀O₁₂
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityDMSO (>1 mg/ml) or ethanol (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2-3 months at -20°C.
      Toxicity Irritant
      ReferencesJothi, M., et al. 2013. Mol. Cancer Ther. In press.
      Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
      Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
      Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
      Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
      Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
      Wong, W.L., et al. 1993. Biochem. J. 289, 71.
      Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
      Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
      Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
      Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.