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530409 TLR8 Agonist, cpd14b - CAS 1607440-08-3 - Calbiochem

A potent agonist of Toll-like receptor 8 agonist (TLR8, EC₅₀ = 200 nM).

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Toll-Like Receptor 8 Agonist

Primary Target: TLR8
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CAS #Empirical Formula
1607440-08-3C₁₄H₁₈N₂

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      Description
      OverviewA pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC50 = 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/ml).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530409
      Brand Family Calbiochem®
      SynonymsToll-Like Receptor 8 Agonist
      References
      ReferencesKokatla, H. P., et al. 2014, ChemMedChem9, 719.
      Product Information
      CAS number1607440-08-3
      FormWhite powder
      Hill FormulaC₁₄H₁₈N₂
      Chemical formulaC₁₄H₁₈N₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTLR8
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      5304090001 04055977260793

      Documentation

      TLR8 Agonist, cpd14b - CAS 1607440-08-3 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Riferimenti bibliografici

      Panoramica delle referenze
      Kokatla, H. P., et al. 2014, ChemMedChem9, 719.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-June-2014 JSW
      SynonymsToll-Like Receptor 8 Agonist
      DescriptionA pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC50 = 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/ml).
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1607440-08-3
      Chemical formulaC₁₄H₁₈N₂
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKokatla, H. P., et al. 2014, ChemMedChem9, 719.