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574775 Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem

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Tabella delle specifiche principali

CAS #Empirical Formula
72741-87-8C₈H₁₅NO₃

Prezzi e disponibilità

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574775-500UG
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      Description
      OverviewReversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.
      Catalogue Number574775
      Brand Family Calbiochem®
      Synonyms(1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol
      References
      ReferencesMochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
      Elbein, A.D. 1983. Methods Enzymol. 98, 135.
      Product Information
      CAS number72741-87-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₅NO₃
      Chemical formulaC₈H₁₅NO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetLysosomal α-mannosidase
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      574775-500UG 04055977189711

      Documentation

      Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      574775

      Riferimenti bibliografici

      Panoramica delle referenze
      Mochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
      Elbein, A.D. 1983. Methods Enzymol. 98, 135.

      Citazioni

      Titolo
    • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
    • Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      Synonyms(1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol
      DescriptionReversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.
      FormWhite solid
      CAS number72741-87-8
      Chemical formulaC₈H₁₅NO₃
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (5 mg/ml), H₂O (1 mg/ml), or Chloroform
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Harmful
      ReferencesMochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
      Elbein, A.D. 1983. Methods Enzymol. 98, 135.
      Citation
    • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.