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569406 Stearoyl-CoA Desaturase 1 Inhibitor, MF-438 - Calbiochem

Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, CAS 921605-87-0, is a cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1; IC50 of 2.3 nM).

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole

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569406
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569406-10MG
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      Description
      OverviewA cell-permeable, thiadiazole-pyridazine compound that acts as an inhibitor of Stearoyl-CoA Desaturase 1 (SCD1) with an IC50 of 2.3 nM. In vivo, it exhibits an ED50 of 1-3 mg/kg, p.o., in mouse liver PD assays.
      Catalogue Number569406
      Brand Family Calbiochem®
      Synonyms2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole
      References
      ReferencesLeger, S., et al. 2010. Bioorg Med Chem Lett. 2, 499.
      Product Information
      FormOff-white powder
      Hill FormulaC₁₉H₁₈F₃N₅OS
      Chemical formulaC₁₉H₁₈F₃N₅OS
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationStearoyl-CoA Desaturase 1 Inhibitor, MF-438, CAS 921605-87-0, is a cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1; IC50 of 2.3 nM).
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      569406-10MG 04055977190557

      Documentation

      Stearoyl-CoA Desaturase 1 Inhibitor, MF-438 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Stearoyl-CoA Desaturase 1 Inhibitor, MF-438 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      569406

      Riferimenti bibliografici

      Panoramica delle referenze
      Leger, S., et al. 2010. Bioorg Med Chem Lett. 2, 499.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-May-2013 JSW
      Synonyms2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole
      DescriptionA cell-permeable, thiadiazole-pyridazine compound that acts as an inhibitor of Stearoyl-CoA Desaturase 1 (SCD1) with an IC50 of 2.3 nM. In vivo, it exhibits an ED50 of 1-3 mg/kg, p.o., in mouse liver PD assays.
      FormOff-white powder
      Chemical formulaC₁₉H₁₈F₃N₅OS
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLeger, S., et al. 2010. Bioorg Med Chem Lett. 2, 499.