566660 Sigma-AldrichSmoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem
A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM).
More>> A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Less<<Sinonimi: N-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3
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Tabella delle specifiche principali
CAS # | Empirical Formula |
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364590-63-6 | C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O |
Prezzi e disponibilità
Numero di catalogo | Disponibilità | Confezionamento | Qtà/conf | Prezzo | Quantità | |
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566660-1MG |
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Bottiglia di vetro | 1 mg |
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566660-5MG |
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Bottiglia di vetro | 5 mg |
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Description | |
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Overview | A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50 = ∼ 3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566661) in H2O is also available. |
Catalogue Number | 566660 |
Brand Family | Calbiochem® |
Synonyms | N-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3 |
Product Information | |
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CAS number | 364590-63-6 |
Form | Light yellow solid |
Hill Formula | C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O |
Chemical formula | C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O |
Hygroscopic | Hygroscopic |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Purity | ≥98% by HPLC |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Numero di catalogo | GTIN |
566660-1MG | 07790788051570 |
566660-5MG | 04055977191578 |