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573096 STAT3 Inhibitor Peptide, Cell-Permeable

STAT3 Inhibitor Peptide, Cell-Permeable, is an analog of Stat3-SH2 domain-binding phosphopeptide with a C-terminal membrane translocating sequence. A selective, potent blocker of Stat3 activation.

STAT3 Inhibitor Peptide, Cell-Permeable: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: PpYLKTK-mts, STAT3 Inhibitor IV

Primary Target: Blocker of Stat3 activation
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573096
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₉₂H₁₅₇N₂₀O₂₄P

Prezzi e disponibilità

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573096-1MG
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      573096-5MG
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      Disponibili quantità limitate
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          Prodotti rimanenti: riceverà un nostro avviso
          Will advise
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          Contact Customer Service

          		 Fiala di plastica 5 mg
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          Description
          OverviewA cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. The unphosphorylated inactive control peptide is also available under Cat. No. 573105.
          Supplied as a trifluoroacetate salt.
          Catalogue Number573096
          Brand Family Calbiochem®
          SynonymsPpYLKTK-mts, STAT3 Inhibitor IV
          References
          ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
          Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₉₂H₁₅₇N₂₀O₂₄P
          Chemical formulaC₉₂H₁₅₇N₂₀O₂₄P
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          ApplicationSTAT3 Inhibitor Peptide, Cell-Permeable, is an analog of Stat3-SH2 domain-binding phosphopeptide with a C-terminal membrane translocating sequence. A selective, potent blocker of Stat3 activation.
          Biological Information
          Primary TargetBlocker of Stat3 activation
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceH-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Numero di catalogo GTIN
          573096-1MG 07790788051730
          573096-5MG 07790788051747

          Documentation

          STAT3 Inhibitor Peptide, Cell-Permeable MSDS

          Titolo

          Scheda di sicurezza (MSDS) 

          STAT3 Inhibitor Peptide, Cell-Permeable Certificati d'Analisi

          TitoloNumero di lotto
          573096

          Riferimenti bibliografici

          Panoramica delle referenze
          Turkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
          Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.

          Brochure

          Titolo
          An Introduction to Inhibitors and Their Biological Applications - 1st Edition

          Informazioni tecniche

          Titolo
          JAK/STAT Signaling Research Focus

          Citazioni

          Titolo
        • Rob D. Catalano, et al. (2005) Inhibition of STAT3 activation in the endometrium prevents implantation: a nonsteroidal approach to contraception. Proceedings of the National Academy of Science USA in press,.
        • Yoshinari Tanabe, et al. (2005) Role of STAT1, STAT3, and STAT5 in IFN-αβ responses in T lymphocytes. Journal of Immunology 174, 609-613.
        • Egle Avizienyte, et al. (2004) Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Molecular Biology of the Cell 15, 2794-2803.
          		•
          Scheda tecnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2008 RFH
          SynonymsPpYLKTK-mts, STAT3 Inhibitor IV
          DescriptionA cell-permeable analog of the Stat3-SH2 domain-binding phospho-peptide (Cat. No. 573095) that contains a C-terminal membrane translocating sequence (MTS) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat3-dependent Src transformation with no effect on Stat3-independent Ras transformation.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₉₂H₁₅₇N₂₀O₂₄P
          Peptide SequenceH-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
          Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.
          Citation
        • Rob D. Catalano, et al. (2005) Inhibition of STAT3 activation in the endometrium prevents implantation: a nonsteroidal approach to contraception. Proceedings of the National Academy of Science USA in press,.
        • Yoshinari Tanabe, et al. (2005) Role of STAT1, STAT3, and STAT5 in IFN-αβ responses in T lymphocytes. Journal of Immunology 174, 609-613.
        • Egle Avizienyte, et al. (2004) Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Molecular Biology of the Cell 15, 2794-2803.
          		•