Millipore Sigma Vibrant Logo

557366 Rosiglitazone - CAS 155141-29-0 - Calbiochem

A thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-γ (PPARγ) (Kd ~40 nM) in fat cells.

Rosiglitazone - CAS 155141-29-0 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 5-[4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl]thiazolidine-2,4-dione, BRL49653, Avandia, AMPK Signaling Activator X, PPAR Agonist X, PPARγ Agonist IX

View Products on Sigmaaldrich.com
557366
Visualizza prezzi e disponibilità

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
155141-29-0C₁₈H₁₉N₃O₃S.C₄H₄O₄

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
557366-10MG
Verifica della disponibilità in corso...
—
Disponibilità limitata Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      		 Bottiglia di vetro 10 mg
      Ricerca del prezzo in corso...
      Non è stato possibile trovare il prezzo
      La quantità minima deve essere un multiplo di
      Maximum Quantity is
      Al termine dell'ordine Maggiori informazioni
      Lei ha salvato ()
       
      —
      Richiedi il prezzo
      		 —
      Description
      OverviewA thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-g (PPARg) (Kd ~40 nM) in fat cells. Shown to reduce fatty acid uptake and ameliorate lipid metabolism and insulin resistance in animal models of type II diabetes. Reported to activate both a1- and a2-containing AMPK complexes. Unlike troglitazone, it does not induce the activity of P4503A4. Significantly improves the differentiation of C3H10T1/2 stem cells into adipocytes. Shown to block estrogen synthesis by interfering with androgen binding to aromatase, but without affecting aromatase mRNA or protein expression.
      Catalogue Number557366
      Brand Family Calbiochem®
      Synonyms5-[4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl]thiazolidine-2,4-dione, BRL49653, Avandia, AMPK Signaling Activator X, PPAR Agonist X, PPARγ Agonist IX
      References
      ReferencesAraki, T., et al. 2011. PPAR Res. 2011, 926438.
      Sozio, M. S., et al. 2011. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G739.
      Gerstein, H., et al. 2006. Drug 368, 9541.
      Mohanty, P., 2004. Journ. Clin. Endocrin. & Metab. 89(6), 2728-2735.
      Fryer, L., et al. 2002. J Biol Chem 277, 25226.
      Goldberg, R., et al. 1999. Drug. 57, 921.
      Young, P., et al. 1998. Journ. Pharm. Exp. Ther. 284, 751.
      Willson, T., et al. 1996. J. Med. Chem.39, 665; Lehmann, J., et al., 1995. JBC 270, 12953.
      Cantello, B., et al., 1994. Bioorg. Med. Chem. Lett. 4, 1181.
      Product Information
      CAS number155141-29-0
      FormWhite powder
      Hill FormulaC₁₈H₁₉N₃O₃S.C₄H₄O₄
      Chemical formulaC₁₈H₁₉N₃O₃S.C₄H₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      557366-10MG 04055977268027

      Documentation

      Rosiglitazone - CAS 155141-29-0 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Rosiglitazone - CAS 155141-29-0 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      557366

      Riferimenti bibliografici

      Panoramica delle referenze
      Araki, T., et al. 2011. PPAR Res. 2011, 926438.
      Sozio, M. S., et al. 2011. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G739.
      Gerstein, H., et al. 2006. Drug 368, 9541.
      Mohanty, P., 2004. Journ. Clin. Endocrin. & Metab. 89(6), 2728-2735.
      Fryer, L., et al. 2002. J Biol Chem 277, 25226.
      Goldberg, R., et al. 1999. Drug. 57, 921.
      Young, P., et al. 1998. Journ. Pharm. Exp. Ther. 284, 751.
      Willson, T., et al. 1996. J. Med. Chem.39, 665; Lehmann, J., et al., 1995. JBC 270, 12953.
      Cantello, B., et al., 1994. Bioorg. Med. Chem. Lett. 4, 1181.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-August-2012 JSW
      Synonyms5-[4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl]thiazolidine-2,4-dione, BRL49653, Avandia, AMPK Signaling Activator X, PPAR Agonist X, PPARγ Agonist IX
      DescriptionA thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-g (PPARg) (Kd ~40 nM) in fat cells. Shown to reduce fatty acid uptake and ameliorate lipid metabolism and insulin resistance in animal models of type II diabetes. Reported to activate both a1- and a2-containing AMPK complexes. Unlike troglitazone, it does not induce the activity of P4503A4. Significantly improves the differentiation of C3H10T1/2 stem cells into adipocytes. Shown to block estrogen synthesis by interfering with androgen binding to aromatase, but without affecting aromatase mRNA or protein expression.
      FormWhite powder
      CAS number155141-29-0
      Chemical formulaC₁₈H₁₉N₃O₃S.C₄H₄O₄
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAraki, T., et al. 2011. PPAR Res. 2011, 926438.
      Sozio, M. S., et al. 2011. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G739.
      Gerstein, H., et al. 2006. Drug 368, 9541.
      Mohanty, P., 2004. Journ. Clin. Endocrin. & Metab. 89(6), 2728-2735.
      Fryer, L., et al. 2002. J Biol Chem 277, 25226.
      Goldberg, R., et al. 1999. Drug. 57, 921.
      Young, P., et al. 1998. Journ. Pharm. Exp. Ther. 284, 751.
      Willson, T., et al. 1996. J. Med. Chem.39, 665; Lehmann, J., et al., 1995. JBC 270, 12953.
      Cantello, B., et al., 1994. Bioorg. Med. Chem. Lett. 4, 1181.