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554328 Resveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem

A cell-permeable triacetate resveratrol prodrug that is easily converted to resveratrol by esterase activity and exhibits similar bioactivity as resveratrol in cell cultures.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: trans-3,5,4ʹ-Triacetylstilbene, 3,5,4ʹ-Tri-O-acetylresveratrol

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554328
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Tabella delle specifiche principali

CAS #Empirical Formula
42206-94-0C₂₀H₁₈O₈

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554328-25MG
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      Description
      OverviewA cell-permeable triacetate resveratrol (Cat. No. 554325) prodrug that is easily converted to resveratrol by esterase activity and exhibits similar bioactivity as resveratrol in cell cultures. Cremophor EL is reported to protect the prodrug from fast hydrolysis and resveratrol conversion in mouse serum at 37°C (100% conversion within 20 sec vs. >300 min or T1/2 of 48 min delivered with DMSO or 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O, respectively; [prodrug]t=0 = 100 µM), although the active drug resveratrol is stable for more than 27 h under the same condition without Cremophor EL. When dosed at 10 mg/kg and delivered with 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O intraperitoneally before, but not after, exposure to lethal γ-irradiation (9.75 Gy), the prodrug, but not resveratrol, is shown to greatly prevent irradiation-induced death in mice in vivo (survival rate = 77.4% with 10 mg/kg prodrug vs. ≤28.3% with 10 mg/kg resveratrol, vehicle alone, or no pretreatment at all).
      Catalogue Number554328
      Brand Family Calbiochem®
      Synonymstrans-3,5,4ʹ-Triacetylstilbene, 3,5,4ʹ-Tri-O-acetylresveratrol
      References
      ReferencesKoide, K., et al. 2011. ACS Med. Chem. Lett. 2, 270.
      Hsieh, T.C., et al. 2011. Int. J. Cancer 129, 2732.
      Product Information
      CAS number42206-94-0
      FormWhite powder
      Hill FormulaC₂₀H₁₈O₈
      Chemical formulaC₂₀H₁₈O₈
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      554328-25MG 04055977193060

      Documentation

      Resveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Resveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      554328

      Riferimenti bibliografici

      Panoramica delle referenze
      Koide, K., et al. 2011. ACS Med. Chem. Lett. 2, 270.
      Hsieh, T.C., et al. 2011. Int. J. Cancer 129, 2732.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-December-2011 RFH
      Synonymstrans-3,5,4ʹ-Triacetylstilbene, 3,5,4ʹ-Tri-O-acetylresveratrol
      DescriptionA cell-permeable triacetate resveratrol (Cat. No. 300 min or T1/2 of 48 min delivered with DMSO or 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O, respectively; [prodrug]t=0 = 100 µM), although the active drug resveratrol is stable for more than 27 h under the same condition without Cremophor EL. When dosed at 10 mg/kg and delivered with 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O intraperitoneally before, but not after, exposure to lethal γ-irradiation (9.75 Gy), the prodrug, but not resveratrol, is shown to greatly prevent irradiation-induced death in mice in vivo (survival rate = 77.4% with 10 mg/kg prodrug vs. ≤28.3% with 10 mg/kg resveratrol, vehicle alone, or no pretreatment at all).
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number42206-94-0
      Chemical formulaC₂₀H₁₈O₈
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesKoide, K., et al. 2011. ACS Med. Chem. Lett. 2, 270.
      Hsieh, T.C., et al. 2011. Int. J. Cancer 129, 2732.